Results 61 to 70 of about 89,980 (338)

Administrative reforms in South Eastern European states. Comparative study in view of enlarging the European Administrative Space. 2010 Sino-US International Conference on Public Administration (5th), June 14-17, 2010, Xiamen City, P.R. China [PDF]

, 2010
The accession and enlargement of the European integration process have determined, especially in the last decade, profound reforms aimed at changing the national public administrations in consensus with the developments of the administrations in the ...
Matei, Lucica, Matei, Ani
core  

The Rulemaking Authority of the Executive Branch of Government – An Analysis of Slovenian and American Theory, Legislation and Case Law

, 2014
The rulemaking function of the executive branch of government is a fact of life in modern democratic states. In terms of development, the importance of secondary legislation is growing in both the quantitative and qualitative sense. Because it represents
Rakar, Iztok
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

الخروج عن مقتضى الواجب الوظيفي الموجب للمسؤوليَّة التأديبيَّة / Violation of Official Duties as Grounds for Disciplinary Liability [PDF]

مجلة البحوث الفقهیة والقانونیة
يقوم النشاط الإداري في الدولة على العديد من العناصر، ومن أهمها العنصر البشري ممثلًا في الموظف العام، فيؤدي الموظف العام عمله من خلال ارتباطه بما يسمَّى بالوظيفة العامة، وبمجرد نشوء العلاقة الوظيفية بين الشخص الطبيعي والسلطة الإدارية يصبح الموظف العام محلّ
عبدالرحمن بن زاحم شرار السلمي
doaj   +1 more source

Ensuring global health: a comprehensive review of vaccine regulation with a focus on the Indian perspective

International Journal of Community Medicine and Public Health
The regulation of vaccines is crucial for ensuring public health and safety. A global perspective on vaccine regulation, with focus on the Indian approach in vaccine regulation, was analysed.
Nitesh Kumar, M. Darshan, Farzana Islam
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Current problems of educational administration in the state of Kuwait [PDF]

, 1987
This research is an inquiry into the current problems and difficulties of educational administration in Kuwait. The study comprises eight chapters. The introduction defines the scope and purpose of the study and the methodology employed.
Al .Musailim, Muhammad Yousef
core  

Systematic Review of Health Communication for Non-Cigarette Tobacco Products

Health Communication, 2017
The Food and Drug Administration, which now has regulatory authority over all tobacco products meeting the statutory definition, is tasked with communicating the risks of these products to the public through health warnings and public education. However,
Jennifer Cornacchione Ross, S. Noar, E. Sutfin   +2 more
semanticscholar   +1 more source