Results 71 to 80 of about 3,243,743 (388)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Transparencia y rendición de cuentas en la filantropía y la inversión social privada [PDF]
, 2015 Esta Caja de herramientas intenta informar a las organizaciones de apoyo que sirven a la filantropía respecto de los elementos esenciales de la transparencia y la rendición de cuentas para la filantropía y la inversión social privada.
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Movimiento Científico, 2016 Objetivo: identificar el acceso a los servicios de salud de las víctimas del conflicto armado, en el escenario del postconflicto. Materiales y métodos: revisión temática de artículos científicos, consultando las bases de datos Medline, The Cochanre ...
Lorena Ramírez Cardona +2 more
doaj +1 more source
Documentación de archivo para la revisión del trabajo arqueológico. El caso de Punta de la Vaca
Revista Atlántica-Mediterránea de Prehistoria y ArqueologÃa Social, 2013 Un tipo de documento frecuente en archivos son las cartas personales y en este articulo trataremos de demostrar como su estudio nos puede ayudar a comprender el analisis historico en general y el de la historia de la Arqueologia en particular. En este trabajo se recoge la informacion extraida de la correspondencia personal entre el padre Fidel Fita y ...
openaire +1 more source
Aneurismas y pseudoaneurismas en fístulas arteriovenosas: revisión de la bibliografía
Revista Mexicana de Angiolog�aLa fístula arteriovenosa para hemodiálisis es fundamental en la terapia renal sustitutiva, sin embargo, no está exenta de complicaciones, incluidos los aneurismas y los pseudoaneurismas. El diagnóstico de estos trastornos no es sencillo y sus complicaciones son potencialmente graves.
Jennifer K. Mondragón-Zamora +9 more
openaire +2 more sources
Emotion regulation and PTSI [PDF]
, 2019 Treball Final de Grau en Psicologia. Codi: PS1048. Curs: 2018/2019.In this review, our aim was to study the relationship between emotion regulation and PTSD.
Salvi Bidart, María Teresa
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source