Results 51 to 60 of about 443,344 (379)
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Self-Supervised Online Reward Shaping in Sparse-Reward Environments [PDF]
arXiv, 2021 We introduce Self-supervised Online Reward Shaping (SORS), which aims to improve the sample efficiency of any RL algorithm in sparse-reward environments by automatically densifying rewards. The proposed framework alternates between classification-based reward inference and policy update steps -- the original sparse reward provides a self-supervisory ...
arxiv
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Preprocessing Reward Functions for Interpretability [PDF]
arXiv, 2022 In many real-world applications, the reward function is too complex to be manually specified. In such cases, reward functions must instead be learned from human feedback. Since the learned reward may fail to represent user preferences, it is important to be able to validate the learned reward function prior to deployment.
arxiv
Negotiating using rewards [PDF]
Artificial Intelligence, 2006 Peer ...
Ramchurn, SD +3 more
openaire +7 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
NeuroImage, 2021 The ability to regulate appetite is essential to avoid food over-consumption. The desire for a particular food can be triggered by its odor before it is even seen.
R. Janet +6 more
doaj
Reward Design in Cooperative Multi-agent Reinforcement Learning for Packet Routing [PDF]
arXiv, 2020 In cooperative multi-agent reinforcement learning (MARL), how to design a suitable reward signal to accelerate learning and stabilize convergence is a critical problem. The global reward signal assigns the same global reward to all agents without distinguishing their contributions, while the local reward signal provides different local rewards to each ...
arxiv
Molecular Oncology, EarlyView.This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke +12 more
wiley +1 more source