Results 61 to 70 of about 442,274 (281)

Language Learning Enhanced by Massive Multiple Online Role-Playing Games (MMORPGs) and the Underlying Behavioral and Neural Mechanisms

Frontiers in Human Neuroscience, 2017
Massive Multiple Online Role-Playing Games (MMORPGs) have increased in popularity among children, juveniles, and adults since MMORPGs’ appearance in this digital age.
Yongjun Zhang, Yongjun Zhang, Hongwen Song, Xiaoming Liu, Xiaoming Liu, Dinghong Tang, Yue-e Chen, Yue-e Chen, Xiaochu Zhang, Xiaochu Zhang, Xiaochu Zhang, Xiaochu Zhang, Xiaochu Zhang   +12 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring governance challenges in South African public organisations

Cogent Social Sciences
Despite the incessant poor service delivery serving as a reminder to the existence of governance challenges, the existing literature gives scant attention to what constitute governance challenges in public organisations.
Ndimphiwe Mlamli Marawu, Reward Utete
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Agenda for future business resilience and survival avenues in crisis times: A systematic literature review of the effects of COVID-19 on SMEs’ productivity in South Africa

Social Sciences and Humanities Open
For handling future crises and to give their businesses the best chance of survival it is imperative that owners and managers of SMEs have a comprehensive understanding of the severity of the impact of the crisis itself.
Nokuphila Yvonne Biyela, Reward Utete
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The link between social comparison orientation and domain-specific risk-taking: exploring the mediating role of two dimensions of trait competitiveness

Frontiers in Psychology
IntroductionOur recent research has demonstrated that social comparison orientation of ability (SCO-ability) is an antecedent of trait competitiveness (TC), and TC mediates the relation between SCO-ability and domain-specific risk-taking.
Yuqian Wang, Andrew J. Elliot, Edmund Derrington, Yansong Li, Yansong Li, Yansong Li   +5 more
doaj   +1 more source

Learning the specific quality of taste reinforcement in larval Drosophila

eLife, 2015
The only property of reinforcement insects are commonly thought to learn about is its value. We show that larval Drosophila not only remember the value of reinforcement (How much?), but also its quality (What?).
Michael Schleyer, Daisuke Miura, Teiichi Tanimura, Bertram Gerber   +3 more
doaj   +1 more source

A Neural Circuit for Gut-Induced Reward.

Cell, 2018
The gut is now recognized as a major regulator of motivational and emotional states. However, the relevant gut-brain neuronal circuitry remains unknown.
Wenfei Han, Luis A. Tellez, Matthew H. Perkins, Isaac O. Perez, Taoran Qu, J. Ferreira, T. L. Ferreira, Danielle Quinn, Zhong-Wu Liu, Xiao-Bing Gao, M. M. Kaelberer, D. Bohórquez, S. J. Shammah-Lagnado, Guillaume de Lartigue, Ivan E. de Araujo   +14 more
semanticscholar   +1 more source