Results 101 to 110 of about 2,052,475 (288)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Shared and Unique Patterns of Dysregulated Dual Systems Between Adolescent Problematic Video Gaming and ADHD

PsyCh Journal
The association between problematic video gaming (PVG) and ADHD has long attracted attention. Dual‐systems models posit that reward sensitivity (RS, the tendency to pursue rewards), inhibitory control (IC, the capacity to suppress prepotent responses ...
Ruijuan Wu, Kunru Song, Yishan Shen, Jintao Zhang, Yueqin Hu   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Predictive effects of temperament on motivation

International Journal of Educational Psychology, 2017
Although temperament and motivation both reflect individual differences in what is perceived as rewarding or threatening, and what is to be approached and what avoided, respectively, we know rather little about how they are connected in educational ...
Anna Maria Rawlings, Anna Tapola, Markku Niemivirta   +2 more
doaj   +1 more source

Does monetary reward operantly enhance pain sensitivity over time? An experiment in healthy individuals

, 2018
Yukiko Shiro,1 Tatsunori Ikemoto,2 Kazuhiro Hayashi,3 Young-Chang Arai,4 Masataka Deie,2 Takefumi Ueno5 1Department of Physical Therapy, Faculty of Rehabilitation Sciences, Nagoya Gakuin University, Aichi, Japan; 2Department of Orthopaedics, Aichi ...
Shiro Y, Hayashi K, Deie M, Arai YC, Ueno T, Ikemoto T   +5 more
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Heightened sensitivity to punishment and reward in anorexia nervosa

Appetite, 2014
The aim of this study was to investigate reinforcement sensitivity in anorexia nervosa (AN). It was tested whether self-reported punishment (PS) and reward sensitivity (RS) differed between adolescents with AN and healthy controls, and/or between AN-subtypes.
Glashouwer, Klaske A, Bloot, Lotte, Veenstra, Esther M, Franken, Ingmar H A, de Jong, Peter J   +4 more
openaire   +2 more sources

Developmental continuity in reward-related enhancement of cognitive control

Developmental Cognitive Neuroscience, 2014
Adolescents engage in more risky behavior than children or adults. The most prominent hypothesis for this phenomenon is that brain systems governing reward sensitivity and brain systems governing self-regulation mature at different rates.
Nicole M. Strang, Seth D. Pollak
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Social Reward Shaping in the Prisoner's Dilemma

, 2008
Reward shaping is a well-known technique applied to help reinforcement-learning agents converge more quickly to near-optimal behavior. In this paper, we introduce social reward shaping, which is reward shaping applied in the multiagent-learning framework.
Munoz de Cote, Enrique, Littman, Michael L., Babes, Monica   +2 more
core   +1 more source