Results 91 to 100 of about 2,052,475 (288)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Is Reward A Punishment? from Reward Addiction to Sensitivity to Punishment

International Journal of Psychology and Educational Studies, 2018
This study introduces the topics of reward addiction and sensitivity to punishment in academic contexts to the literature. This study was designed firstly to develop reliable and valid measurement tools that can measure high school students' reward addiction and sensitivity to punishment in academic contexts, and secondly to test the structural ...
openaire   +3 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Inference of reward and penalty sensitivity based on DDM estimates and reward rate optimization model.

, 2021
(A) Estimated group-level reward-rate-optimal combinations of drift rate and threshold for the four conditions in the experiment (reproduced from Fig 4C).
Harrison Ritz (11883814), Xiamin Leng (11883811), Amitai Shenhav (5143175), Debbie Yee (568287)   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Reward sensitivity in Parkinson's patients with binge eating

Parkinsonism & Related Disorders, 2018
Parkinson's disease (PD) patients who are treated with dopamine replacement therapy are at risk of developing impulse control disorders (ICDs) (such as gambling, binge eating, and others). According to recent evidence, compulsive reward seeking in ICDs may arise from an excessive attribution of incentive salience (or 'wanting') to rewards.In this study,
Terenzi, Damiano, Rumiati, Raffaella, Catalan, Mauro, Antonutti, Lucia, Furlanis, Giovanni, Garlasco, Paolo, Polverino, Paola, Bertolotti, Claudio, Manganotti, Paolo, Aiello, Marilena   +9 more
openaire   +4 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Reward responsivity and the development of nicotine dependence

, 2008
Different theories have been proposed to explain the development of nicotine dependence. Some theories suggest that nicotine has direct reinforcing properties, either positive or negative.
Kalamboka, Natasha
core   +1 more source

Reward reactivity as a buffer against negative mental health consequences of pandemic-related stress: a preregistered analysis in the human connectome project in development

NeuroImage
The COVID-19 pandemic presented numerous novel stressors to youth which have been associated with worsening mental health. Previous work has shown that individuals with high reward sensitivity show resilience in the face of individualized stressors. Here,
Catherine A. Mikkelsen, Emma C. Robertson, Leah H. Somerville, Makeda M. Mayes, Andrew N. Meltzoff, Katie A. McLaughlin, Maya L. Rosen   +6 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source