Results 71 to 80 of about 2,052,475 (288)

Reward Sensitivity Enhances Ventrolateral Prefrontal Cortex Activation During Free Choice

Frontiers in Neuroscience, 2016
Expressing one’s preference via choice can be rewarding, particularly when decisions are voluntarily made as opposed to being forced. An open question is whether engaging in choices involving rewards recruits distinct neural systems as a function of ...
Catherine Cho, David V. Smith, Mauricio R Delgado   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Neural Sensitivity to Social and Monetary Reward in Depression: Clarifying General and Domain-Specific Deficits

Frontiers in Behavioral Neuroscience, 2019
Reward dysfunction is thought to be play a critical role in the pathogenesis of depression. Multiple studies have linked depression to abnormal neural sensitivity to monetary rewards, but it remains unclear whether this reward dysfunction is ...
Belel Ait Oumeziane, Olivia Jones, Dan Foti   +2 more
doaj   +1 more source

Why Dieters Succeed or Fail: The Relationship Between Reward and Punishment Sensitivity and Restrained Eating and Dieting Success

Frontiers in Psychology, 2021
BackgroundThe current study set out to improve our understanding of the characteristics of individuals who are motivated to restrict their food intake yet who nevertheless fail to do so.
Nienke C. Jonker, Elise C. Bennik, Peter J. de Jong   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Evaluating the effect of an individualised reward-related impulsivity induction on ad libitum alcohol consumption: A pilot study

Drug and Alcohol Dependence Reports
Impulsivity has well-documented associations with risky alcohol use. Little evidence exists on the causal mechanisms, but emerging experimental evidence suggests a role for reward-related impulsivity.
Hannah J. Lindsay, Daniel Stjepanović, Matthew J. Gullo   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia

Frontiers in Psychiatry, 2018
Alterations in dopamine neurotransmission are generally associated with diseases such as attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD).
Stefano Cinque, Stefano Cinque, Francesca Zoratto, Anna Poleggi, Damiana Leo, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Enrico Alleva, Raul R. Gainetdinov, Raul R. Gainetdinov, Giovanni Laviola, Walter Adriani, Walter Adriani   +13 more
doaj   +1 more source

Reward sensitivity differs depending on global self-esteem in value-based decision-making

Scientific Reports, 2020
Global self-esteem is a component of individual personality that impacts decision-making. Many studies have discussed the different preferences for decision-making in response to threats to a person’s self-confidence, depending on global self-esteem ...
Aya Ogasawara, Yoshiyuki Ohmura, Yasuo Kuniyoshi   +2 more
doaj   +1 more source