Results 201 to 210 of about 8,159 (227)

Protein landscape of the chromatin states in the malaria parasite Plasmodium falciparum

Ramón-Zamorano G, Mainye S, Kimmel J, de Krijger I, Kanyal A, Horáčková V, Gockel J, Guo Y, Petter M, Graser M, Guillén-Samander A, Vermeulen M, Spielmann T, Bártfai R.   +13 more
europepmc   +1 more source

Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation [PDF]

Developmental Dynamics, 2009
AbstractRex1 (zfp42) is a zinc finger protein expressed primarily in undifferentiated stem cells, both in the embryo and the adult. Upon all‐trans retinoic acid induced differentiation of murine embryonic stem (ES) cells, Rex1 mRNA levels decrease several fold.
Lorraine J Gudas
exaly   +3 more sources

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REX1 and Pf62: are they one and the same?

Parasitology Research, 2009
It was with some interest that we read in Parasitology Research a recent manuscript published online by Moyano et al. (2009) entitled “Initial characterization of Pf62, a novel protein of Plasmodium falciparum identified by immunoscreening”. Analysis of the nucleotide sequence submitted to GenBank in 2002 under accession number AJ493426 indicates that ...
Gardiner, Donald L., Woodcroft, Ben J., Dixon, Matthew W. A., Ralph, Stuart A., Trenholme, Katharine R.   +4 more
openaire   +5 more sources

New insights into regulation of P‐Rex1 autoinhibition

The FASEB Journal, 2022
Phosphatidylinositol 3,4,5‐trisphosphate (PIP3)–dependent Rac exchanger 1 (P‐Rex1) is a guanine nucleotide exchange factor for Rho GTPases downstream of G protein coupled receptors (GPCRs) and tyrosine kinases. It is primarily expressed in hematopoietic cells and brain. Its ectopic expression is reported in different cancers including breast, prostrate,
Sandeep Kaur Ravala, Sheng Li, Chun‐Liang Chen, Michael A. Cianfrocco, Jennifer N. Cash, John J. G. Tesmer   +5 more
openaire   +1 more source

P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer

Cancers, 2020
The GTPase Rac1 is a well-established master regulator of cell motility and invasiveness contributing to cancer metastasis. Dysregulation of the Rac1 signaling pathway, resulting in elevated motile and invasive potential, has been reported in multiple cancers. However, there are limited studies on the regulation of Rac1 in prostate cancer.
Martin J Baker, Martin C Abba, Rafael García-Mata   +2 more
exaly   +4 more sources

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

Nature, 2012
Evolution of the mammalian sex chromosomes has resulted in a heterologous X and Y pair, where the Y chromosome has lost most of its genes. Hence, there is a need for X-linked gene dosage compensation between XY males and XX females. In placental mammals, this is achieved by random inactivation of one X chromosome in all female somatic cells ...
Cristina Gontan, Jeroen A A Demmers, Tahsin Stefan Barakat   +2 more
exaly   +3 more sources

Purification of P‐Rex1 from Neutrophils and Nucleotide Exchange Assay

2006
The P-Rex family of guanine-nucleotide exchange factors (GEFs) are activators of the small GTPase Rac (Donald et al., 2004; Rosenfeldt et al., 2004; Welch et al., 2002). They are directly regulated in vitro and in vivo by the lipid second messenger phosphatidylinositol (3,4,5)-triphosphate (PtdIns(3,4,5)P3) and by the betagamma subunits of ...
Kirsti, Hill, Heidi C E, Welch
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Abstract B147: P-Rex1 is required for efficient melanoma metastasis.

Molecular Cancer Therapeutics, 2011
Abstract Background: P-Rex1 is a Rac-specific Rho GTPase guanine nucleotide exchange factor that has recently been implicated in cancer for the first time. As Rac has a central role in control of cell motility, we assessed the role of P-Rex1 in melanoma, a cancer where metastasis is the major cause of death. This was the first evaluation
Colin R. Lindsay, Samuel Lawn, Andrew Campbell, William Faller, Florian Rambow, Richard Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Mairin Rafferty, Ian Murphy, Enda McDermott, Kieran Sheahan, William Gallacher, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi Welch, Brad Ozanne, Owen Sansom   +20 more
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