Results 201 to 210 of about 177,535 (259)

Quercetin and Cardiovascular Health: An Evidence‐Based Review of Risk Factors and Treatments

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Quercetin is a naturally occurring polyphenolic phytochemical distributed in fruits and vegetables. Quercetin, as a flavonoid, showed significant antioxidant capabilities and potential therapeutic effects on CVD risk factors. Quercetin reduces cardiac hypertrophy and apoptosis in cardiomyocytes by modulating critical signaling pathways.
Mohammad Reza Khazdair, Shima Jafari, Melika Shoghi   +2 more
wiley   +1 more source

Translational reading frame predicts the pathogenicity of C-terminal frameshift deletions in MeCP2. [PDF]

Elife
Guy J, Hein E, Alexander-Howden B, von Bock Und Polach T, Mathieson T, Kleinstiver BP, Zoghbi HY, Bird A.   +7 more
europepmc   +1 more source

Standardized Microplate‐Based Assays for Quantifying Antioxidant Activity in Extracellular Vesicles and Nanovesicles Across Biological Kingdoms

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
ABSTRACT The antioxidant activity of extracellular vesicles (EVs) and nanovesicles are increasingly linked to their physiological and therapeutic functions, yet its accurate quantification remains limited by low EV yield, co‐isolated contaminants and the lack of standardized methodologies.
Juan Antonio Nieto, María‐Carmen López de las Hazas, Victoria Martín‐Santiago, Laura Rubio‐Silvan, Carmen Mazarío‐Gárgoles, Ludovica Attanasio, Benedetta Mercuriali, João Tomé‐Carneiro, Giulia Bernabè, Andrea del Saz‐Lara, Carmen Crespo, María Ángeles Ávila‐Gálvez, Emma Burgos‐Ramos, Juan Carlos Espín, Andrea Chini, Alberto Dávalos   +15 more
wiley   +1 more source

Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function. [PDF]

Mol Pharmacol
Nakhe AY, Dobson JR, Dadi PK, Westover D, Days EL, Vinson P, Weaver CD, Denton JS, Peachee SJ, Behera S, Gibson SE, Rodriguez Da Silva VA, Sela A, Dickerson MT, Jacobson DA.   +14 more
europepmc   +1 more source

RNA‐Binding Protein NOVA1 Restrains Immune Escape and Liver Metastasis in Colorectal Cancer via Stabilizing NRXN1 mRNA

The Journal of Gene Medicine, Volume 28, Issue 11, November 2026.
The RNA‐binding protein neuro‐oncological ventral antigen 1 (NOVA1) is downregulated in colorectal cancer (CRC) and is associated with poor prognosis. NOVA1 binds and stabilizes neurexin 1 (NRXN1) messenger RNA (mRNA), thereby increasing NRXN1 expression and suppressing tumor cell proliferation, invasion, immune evasion, and liver metastasis; NRXN1 ...
ZhiXing Wei, Xing Wei, LinSai Cui, YaXin Pang, Guang Cui, Zhen Wei, ZhaoCai He, BuQiang Wu   +7 more
wiley   +1 more source

ISWI/CHRAC orchestrates sequential chromatin-remodeling activities by mobilizing DNA polymerase ε for homologous recombination. [PDF]

Commun Biol
Qian J, Tanaka K, Yasui A, Ui A.
europepmc   +1 more source

Effects of Deltamethrin and Endosulfan on the Hepatic Markers and Neurobehavioural Alterations in Japanese Quail (Coturnix japonica)

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Japanese quail were exposed to combined low or high doses of deltamethrin and endosulfan by daily oral gavage for 3 weeks. Co‐exposure produced dose‐dependent hepatotoxicity and metabolic disruption, with elevated AST (aspartate aminotransferase), ALP (alkaline phosphatase), LDL, VLDL and cholesterol alongside reduced body and kidney weights.
Saba Malik, Shoaib Ahmad, Muhammad Naeem, Iqra Bibi, Muhammad Sakandar Majid, Hafiza Sadia, Sheeba Riaz, Md Abu Bakkar Siddik   +7 more
wiley   +1 more source

RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes. [PDF]

FASEB J
Adella A, van Katwijk SB, Leermakers PA, van Ham WB, de Ruiter H, Ilgutytė J, Hendrickx S, Nijland L, de Boer TP, van Rooij E, Hoenderop JGJ, de Baaij JHF.   +11 more
europepmc   +1 more source

Cellular Senescence Dysregulates Antiviral Interferon Responses in Idiopathic Pulmonary Fibrosis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent idiopathic pulmonary fibroblasts (IPF) lung fibroblasts are transcriptomically uncoupled from a functional response to virus relative to healthy (HLF) lung fibroblasts. HLF lung fibroblasts require viral effectors STAT1 or IRF3 to enact a viral response while IPF lung fibroblasts do not rely on these axes in response to virus.
Jun‐Wei B. Hughes, Yasmina Reisser, Franziska Hornung, Tyler A. U. Hilsabeck, Fiona Senchyna, Ana L. Coelho, Tsung‐Che Ho, Kevin Schneider, David Furman, Cory M. Hogaboam, Claude Jourdan Le Saux, Pierre‐Yves Desprez, Stefanie Deinhardt‐Emmer   +12 more
wiley   +1 more source

Fibroblastic and myofibroblastic differentiation of cutaneous pleomorphic sarcomas in rabbits. [PDF]

J Vet Med Sci
Niimi H, Isogai S, Tanaka M, Yamazaki R, Imanishi N, Sasai H, Nomura K, Kuwamura M, Izawa T.   +8 more
europepmc   +1 more source