Results 141 to 150 of about 1,119 (155)

Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain. [PDF]

Front Pharmacol
Ding Y.
europepmc   +1 more source

Desaminotyrosine promotes tuft cell expansion and integrates intestinal type 2 immunity. [PDF]

mBio
Zang W, Zhou Z, Shen Y, Zhang B, Chen X, Yue W, Li X, Cai Y, Chen J, Bian J, Huang L, Li H, Dai Y, Yang H.   +13 more
europepmc   +1 more source

The Role of Histone Modifications in Acute Lung Injury: Molecular Mechanisms and Potential of Traditional Chinese Medicine Treatment. [PDF]

J Inflamm Res
Yan Z, Wang J, Qiao J, Xu Z, Wu S, Wang S, Jiao L, Guo T, Tan B, Yang A.   +9 more
europepmc   +1 more source

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RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation

International Immunopharmacology, 2021
Depression is a prevalent mental disorder. However, its pathophysiological mechanism has still remained elusive, and a limited number of effective treatments have been presented. Recent studies have shown that neuroinflammation and microglial activation are involved in the pathogenesis of depression. Histone deacetylase 3 (HDAC3) has neurotoxic effects
He-Tao, Bian, Ling, Xiao, Liang, Liang, Yin-Ping, Xie, Hui-Ling, Wang, Gao-Hua, Wang   +5 more
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RGFP966, a selective HDAC3 inhibitor, ameliorates allergic and inflammatory responses in an OVA-induced allergic rhinitis mouse model

International Immunopharmacology, 2021
RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) playing crucial roles in triggering allergic and inflammatory responses. Whereas, its role in allergic rhinitis (AR) remains uncertain. This study sought to illustrate the role and mechanism of HDAC3 inhibitor RGFP966 on allergic and inflammatory responses in murine AR.
Weitian, Zhang, Xiwen, Sun, Guangyi, Ba, Ru, Tang, Hai, Lin   +4 more
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Histone deacetylase 3-selective inhibitor RGFP966 ameliorates impaired glucose tolerance through β-cell protection

Toxicology and Applied Pharmacology, 2020
The potential therapeutic effect of histone deacetylase 3 (HDAC3) pharmacologic inhibition on diabetes has been focused recently. RGFP966, as a highly-selective HDAC3 inhibitor, its possible roles and underlying mechanism in the treatment of diabetes needs to be clarified. In this study, low-dose streptozotocin (STZ)-induced pre-diabetic mice were used
Lei, Lei, Guoliang, Bai, Xing, Wang, Shuainan, Liu, Jie, Xia, Song, Wu, Yi, Huan, Zhufang, Shen   +7 more
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3D printing of nerve conduits with nanoparticle-encapsulated RGFP966

Applied Materials Today, 2019
Abstract Nerve conduits have great promise for bridging peripheral nerve defects that always cause disability. Currently, the clinically used nerve conduits are limited in promoting nerve regeneration, leading to the unsatisfied nerve repair efficiency.
Xin Xu, Jie Tao, Shuai Wang, Ling Yang, Jiumeng Zhang, Jing Zhang, Haofan Liu, Hao Cheng, Jianguo Xu, Maling Gou, Yuquan Wei   +10 more
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RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7

Biochemical Pharmacology, 2020
Glioma stem cells (GSC) play a major role in drug resistance and tumor recurrence. Using a genetic screen with a set of shRNAs that can target chromatin regulators in a GSC model, we have HDAC3 as a major negative regulator of GSC differentiation.
Hang, Liang, Qian, Wang, Ding, Wang, Hongwu, Zheng, Dhan V, Kalvakolanu, Hua, Lu, Naiyan, Wen, Xuyang, Chen, Libo, Xu, Jiaxin, Ren, Baofeng, Guo, Ling, Zhang   +11 more
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HDAC3 Inhibitor RGFP966 Ameliorated Neuroinflammation in the Cuprizone-Induced Demyelinating Mouse Model and LPS-Stimulated BV2 Cells by Downregulating the P2X7R/STAT3/NF-κB65/NLRP3 Activation

ACS Chemical Neuroscience, 2022
Suppression of excessive microglial overactivation can prevent the progression of multiple sclerosis (MS). Histone deacetylases 3 inhibitor (HDAC3i) has been demonstrated to exert anti-inflammatory effects by suppressing microglia (M1-liked) activation.
Wei Sun, Ning Zhang, Bingyi Liu, Junrong Yang, Gabriele Loers, Hans-Christian Siebert, Min Wen, Xuexing Zheng, Zhengping Wang, Jun Han, Ruiyan Zhang   +10 more
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