Results 151 to 155 of about 1,119 (155)

RGFP966 inhibits palmitic acid induced VSMCs phenotypic transition by targeting ATGL

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
The phenotypic switch of vascular smooth muscle cells (VSMCs) underlies the pathology of many cardiovascular diseases. Histone deacetylase 3 (HDAC3) is reported to upregulate in several cardiovascular diseases. RGFP966 is a highly selective HDAC3 inhibitor.
Siyi, Zhang, Fangqin, Nie, Youjie, Zeng, Zhousheng, Yang, Wenmin, Song, Xin, Yan, Zizhao, Tang, Yangxia, Fu, Ren, Guo   +8 more
openaire   +2 more sources

Inhibition of histone deacetylase 3 via RGFP966 facilitates cortical plasticity underlying unusually accurate auditory associative cue memory for excitatory and inhibitory cue-reward associations

Behavioural Brain Research, 2019
Epigenetic mechanisms are key for regulating long-term memory (LTM) and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. One epigenetic mechanism is chromatin modification by histone acetylation. Blocking the action of histone de-acetylases (HDACs) that normally negatively regulate LTM
Andrea Shang, Sooraz Bylipudi, Kasia M. Bieszczad   +2 more
openaire   +2 more sources

Inhibition of histone deacetylase 3 via RGFP966 facilitates unusually accurate cue memory for excitatory and inhibitory cue-reward associations

2018
Epigenetic mechanisms are key for regulating long-term memory (LTM) and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. One epigenetic mechanism is chromatin modification by histone acetylation. Blocking the action of histone de-acetylases (HDACs) that normally negatively regulate LTM
Shang, Andrea, Bylipudi, Sooraz, Bieszczad, Kasia M.   +2 more
openaire   +1 more source

Inhibition of histone deacetylase 3 via RGFP966 facilitates exceptionally specific and enduring memory for excitatory and inhibitory sound-signal associations

2018
Epigenetic mechanisms that modulate gene expression are key to regulating long-term memory (LTM) formation, and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. Chromatin modifications have been shown to have powerful effects on experience-dependent transcription for neuroplasticity ...
openaire   +1 more source

Corrigendum to “RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7” [Biochem. Pharmacol. 180 (2020) 114118]

Biochemical Pharmacology, 2020
Hang Liang, Qian Wang, Ding Wang, Hongwu Zheng, Dhan V. Kalvakolanu, Hua Lu, Naiyan Wen, Xuyang Chen, Libo Xu, Jiaxin Ren, Baofeng Guo, Ling Zhang   +11 more
openaire   +1 more source