Results 111 to 120 of about 798,356 (283)

Inter‐atrial block as a predictor of adverse outcomes in patients with HFpEF

ESC Heart Failure, EarlyView.
Abstract Aims Inter‐atrial block (IAB), a marker of electrical atrial dysfunction, is associated with an increased risk of atrial fibrillation (AF) and adverse events in various populations. The prognostic impact of IAB in heart failure (HF) with preserved ejection fraction (HFpEF) remains unknown.
Jerremy Weerts, Sanne G.J. Mourmans, Helena Lopez‐Martinez, Mar Domingo, Arantxa Barandiarán Aizpurua, Michiel T.H.M. Henkens, Anouk Achten, Josep Lupón, Hans‐Peter Brunner‐La Rocca, Christian Knackstedt, Antoni Bayés‐Genís, Vanessa P.M. van Empel   +11 more
wiley   +1 more source

Nonlinear Modal Decoupling of Multi-Oscillator Systems with Applications to Power Systems [PDF]

arXiv, 2016
Many natural and manmade dynamical systems that are modeled as large nonlinear multi-oscillator systems like power systems are hard to analyze. For such a system, we propose a nonlinear modal decoupling (NMD) approach inversely constructing as many decoupled nonlinear oscillators as the system oscillation modes so that individual decoupled oscillators ...
arxiv  

Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure—A prospective cohort study

ESC Heart Failure, EarlyView.
The prognostic impact of the muscle parameters gait speed, handgrip strength and appendicular skeletal muscle index on cardiovascular outcomes was investigated. We prospectively analyzed a cohort of 205 heart failure patients with a median left ventricular ejection fraction of 37% and a median follow‐up of 4.7 years.
Vladimir Cejka, Hermann Riepl, Nora Schwegel, Ewald Kolesnik, David Zach, Viktoria Santner, Viktoria Höller, Natascha Schweighofer, Barbara Obermayer‐Pietsch, Thomas Pieber, Caroline Morbach, Stefan Frantz, Andreas Zirlik, Dirk von Lewinski, Stefan Störk, Florian Posch, Klemens Ablasser, Nicolas Verheyen   +17 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Cortactin: A universal host cytoskeletal target of Gram‐negative and Gram‐positive bacterial pathogens

Molecular Microbiology, Volume 118, Issue 6, Page 623-636, December 2022., 2022
In host‐pathogen interactions, actin‐cytoskeletal dynamics play a crucial role in successful adherence, invasion, and intracellular motility by many intruding microbes. To achieve this goal, bacterial pathogens target major host regulators, one of which is the key actin‐binding protein and class‐II actin nucleation‐promoting factor cortactin.
Irshad Sharafutdinov, Jakob Knorr, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer   +4 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

A behavioural approach to port-controlled systems [PDF]

arXiv
We give insight in the structure of port-Hamiltonian systems as control systems in between two closed Hamiltonian systems. Using the language of category theory, we identify systems with their behavioural representation and view a port-control structure with desired structural properties on a given closed system as an extension of this system which ...
arxiv  

MOLECULAR BASIS DETERMINATION OF D VARIANTS: NARRATIVE REVIEW

Hematology, Transfusion and Cell Therapy
Objective: The Rh blood group is one of the most complex blood groups known in humans, being is clinically relevant mainly due to the fact that antigens are highly immunogenic, responsible for a hemolytic transfusion reaction or on fetal RBCs.
ACS Castro, MOO Nascimento, MMP Luciano, JNV Silva, EJS Freitas, IPC Tavares, SRL Albuquerque, RS Leal, MS Gonçalves, JPM Neto   +9 more
doaj  

Occupationally Relevant Zinc‐ and Copper‐Containing Metal Fumes Inhibit Human THP‐1 Macrophage TNF and IL‐6 Responses to Bacterial Stimuli

Global Challenges, EarlyView.
Metal workers have an increased risk of severe pneumonia due to metal fume exposure. In this study, zinc oxide (ZnO) and copper oxide (CuO) particles are found to inhibit specific anti‐bacterial macrophage responses, which may substantially contribute to impaired lung immunity.
Jan Steffens, Sabrina Michael, Katharina Kuth, Henner Hollert, Miriam Du Marchie Sarvaas, Andrijana Nesic, Thomas Kraus, Ralf Baumann   +7 more
wiley   +1 more source

System Identification Under Multi-rate Sensing Environment [PDF]

arXiv
This paper proposes a system identification algorithm for systems with multi-rate sensors in a discrete-time framework. It is challenging to obtain an accurate mathematical model when the ratios of inputs and outputs are different in the system. A cyclic reformulation-based model for multi-rate systems is formulated, and the multi-rate system can be ...
arxiv