Results 71 to 80 of about 811,365 (303)

Using Structure-Behavior Coalescence Method for Systems Definition 2.0 [PDF]

arXiv, 2021
Systems definition is an artifact created by humans to describe what a system is. A system has been defined, by systems definition 1.0, hopefully to be an integrated whole, embodied in its components, their interrelationships with each other and the environment, and the principles and guidelines governing its design and evolution.
arxiv  

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

PRR analysis in rat retina tissue with complicated pregnancy with Preeclampsia

Revista Cubana de Investigaciones Biomédicas, 2020
Introduction: In pregnancy, women experience profound physical, morphological and metabolic changes. Alterations in these changes cause complications such as preeclampsia (PE).
Claudia Ramírez–Montero, Pedro López-Sánchez, Liliana Anguiano–Robledo, Virgilio Lima –Gómez   +3 more
doaj  

Morphisms of Networks of Hybrid Open Systems [PDF]

arXiv, 2019
This thesis (defended 10/07/2019) develops a theory of networks of hybrid open systems and morphisms. It builds upon a framework of networks of continuous-time open systems as product and interconnection. We work out categorical notions for hybrid systems, deterministic hybrid systems, hybrid open systems, networks of hybrid open systems, and morphisms
arxiv  

Contraction analysis of time-varying DAE systems via auxiliary ODE systems [PDF]

arXiv, 2023
This paper studies the contraction property of time-varying differential-algebraic equation (DAE) systems by embedding them to higher-dimension ordinary differential equation (ODE) systems. The first result pertains to the equivalence of the contraction of a DAE system and the uniform global exponential stability (UGES) of its variational DAE system ...
arxiv  

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

First integrals of ordinary linear differential systems [PDF]

arXiv, 2012
The spectral method for building first integrals of ordinary linear differential systems is elaborated. Using this method, we obtain bases of first integrals for linear differential systems with constant coefficients, for linear nonautonomous differential systems integrable in closed form (algebraic reducible systems, triangular systems, the Lappo ...
arxiv  

ERYTHROCYTE BLOOD GROUP ANTIGENS AND ALTERATIONS OF THE HORMONAL STATUS AMONG THE REPRODUCTIVE AGE WOMEN WITH BREAST TUMORS

, 2014
The significance of ABO blood system groups antigens in development of some malignant tumors is already established. The alteration of  hormonal homeostasis must also be taken into account.
I. Nakashidze, N. Kotrikadze, A. Diasamidze, M. Nagervadze, M. Alibegashvili, L. Ramishvili, M. Gordeziani   +6 more
semanticscholar   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source