Results 51 to 60 of about 2,812 (188)

The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication.

PLoS Pathogens, 2022
RSK1, an essential cellular kinase for Kaposi's sarcoma-associated herpesvirus (KSHV) replication, is highly phosphorylated and SUMOylated during KSHV lytic cycle, which determine the substrate phosphorylation and specificity of RSK1, respectively ...
Zhenshan Liu, Xin Wang, Chengrong Liu, Hongying Deng, Wenshu Li, Xiaoqian Wang, Xue Xu, Maggie Z X Xiao, Chunxia Wang, Yucai Zhang, Joyce Fu, Fanxiu Zhu, Qiming Liang   +12 more
doaj   +1 more source

The functions of herpesvirus-encoded microRNAs [PDF]

, 2008
Bioinformatic and direct cloning approaches have led to the identification of over 100 novel miRNAs expressed in DNA viruses, although the function of the majority of these small regulatory RNA molecules is unclear. Recently, a number of reports have now
Grey, Finn, Hook, Lauren, Nelson, Jay
core   +1 more source

Viral pseudoenzymes in infection and immunity

The FEBS Journal, Volume 287, Issue 19, Page 4300-4309, October 2020., 2020
Viral pseudoenzymes are represented by enzyme‐deficient homologs of glutamine amidotransferase (GAT), kinase, and superoxide dismutase that modulate the signaling output in immune defense, viral genome replication, and cell proliferation, respectively.
Ting‐Yu Wang, Jun Zhao, Ali Can Savas, Shu Zhang, Pinghui Feng   +4 more
wiley   +1 more source

Japanese Macaque Rhadinovirus Encodes a Viral MicroRNA Mimic of the miR-17 Family [PDF]

Journal of Virology, 2016
ABSTRACT Japanese macaque (JM) rhadinovirus (JMRV) is a novel, gamma-2 herpesvirus that was recently isolated from JM with inflammatory demyelinating encephalomyelitis (JME). JME is a spontaneous and chronic disease with clinical characteristics and immunohistopathology comparable to those of multiple sclerosis in humans.
Rebecca L, Skalsky, Sarah A, Barr, Andrew J, Jeffery, Tiffany, Blair, Ryan, Estep, Scott W, Wong   +5 more
openaire   +2 more sources

Genome-wide gene expression analysis of anguillid herpesvirus 1 [PDF]

, 2013
<p>Background: Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses.
Davison, A.J., Engelsma, M.Y., Peeters, B.P.H., Rottier, P.J.M., van Beurden, S.J.   +4 more
core   +3 more sources

A Unique Protein Self‐Assembling Nanoparticle with Significant Advantages in Vaccine Development and Production

Journal of Nanomaterials, Volume 2020, Issue 1, 2020., 2020
Nanoparticles are playing an increasingly powerful role in vaccine development. Here, we report the repurposing of nonstructural proteins 10 and 11 (hereafter NSP10) from the replicase polyprotein 1a (pp1a) of the human SARS coronavirus (severe acute respiratory syndrome) as a novel self‐assembling platform for bioengineered nanoparticles for a variety
Daniel C. Carter, Brenda Wright, W. Gray Jerome, John P. Rose, Ellen Wilson, Laura Martinez Maestro   +5 more
wiley   +1 more source

Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells [PDF]

Gene Therapy, 2010
The rhadinovirus herpesvirus saimiri (HVS) as a gene delivery vector allows large DNA insertions and long-termed gene expression. In the case of T-cell transduction, such vectors use the viral transformation-associated genes of HVS C488 for T-cell amplification. In this report, we investigated whether the gene for the catalytic telomerase subunit human
T, Toptan, A, Ensser, H, Fickenscher
openaire   +2 more sources

Guinea pig herpes like virus is a gamma herpesvirus. [PDF]

Virus Genes
Guinea Pig Herpes-Like Virus (GPHLV) is a virus isolated from leukemic guinea pigs with herpes virus-like morphology described by Hsiung and Kaplow in 1969.
Stanfield BA, Ruiz E, Chouljenko VN, Kousoulas KG.   +3 more
europepmc   +3 more sources

Myeloid infection links epithelial and B cell tropisms of Murid Herpesvirus-4.

PLoS Pathogens, 2012
Gamma-herpesviruses persist in lymphocytes and cause disease by driving their proliferation. Lymphocyte infection is therefore a key pathogenetic event.
Bruno Frederico, Ricardo Milho, Janet S May, Laurent Gillet, Philip G Stevenson   +4 more
doaj   +1 more source

Characterization of the Complement Inhibitory Function of Rhesus Rhadinovirus Complement Control Protein (RCP) [PDF]

Journal of Biological Chemistry, 2009
Rhesus rhadinovirus (RRV) is currently the closest known, fully sequenced homolog of human Kaposi sarcoma-associated herpesvirus. Both these viruses encode complement inhibitors as follows: Kaposi sarcoma-associated herpesvirus-complement control protein (KCP) and RRV-complement control protein (RCP).
Okroj, M, Mark, L, Stokowska, A, Wong, SW, Rose, N, Blackbourn, DJ, Villoutreix, BO, Spiller, OB, Blom, AM   +8 more
openaire   +3 more sources