Results 51 to 60 of about 405 (139)

Human Herpesvirus 8--the First Human Rhadinovirus

JNCI Monographs, 1998
Kaposi's sarcoma (KS)-associated herpesvirus, also known as human herpesvirus 8 (HHV-8), is the first known human member of the genus Rhadinovirus. It is regularly found by polymerase chain reaction in all forms of KS, in certain types of Castleman's disease, and in body cavity-based B-cell lymphoma.
F, Neipel, J C, Albrecht, B, Fleckenstein   +2 more
openaire   +2 more sources

Rhesus rhadinovirus vIRF R12 disrupts the PML-nuclear body via proteasome-dependent protein degradation pathway

, 2023
Kaposi’s Sarcoma (KS), a common HIV-associated malignancy, is caused by KS-associated herpesvirus (KSHV). Due to limited models for KSHV infection, rhesus macaque rhadinovirus (RRV), a close homolog, serves as a surrogate.
Gao, Lu
core   +1 more source

The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication.

PLoS Pathogens, 2022
RSK1, an essential cellular kinase for Kaposi's sarcoma-associated herpesvirus (KSHV) replication, is highly phosphorylated and SUMOylated during KSHV lytic cycle, which determine the substrate phosphorylation and specificity of RSK1, respectively ...
Zhenshan Liu, Xin Wang, Chengrong Liu, Hongying Deng, Wenshu Li, Xiaoqian Wang, Xue Xu, Maggie Z X Xiao, Chunxia Wang, Yucai Zhang, Joyce Fu, Fanxiu Zhu, Qiming Liang   +12 more
doaj   +1 more source

Viral pseudoenzymes in infection and immunity

The FEBS Journal, Volume 287, Issue 19, Page 4300-4309, October 2020., 2020
Viral pseudoenzymes are represented by enzyme‐deficient homologs of glutamine amidotransferase (GAT), kinase, and superoxide dismutase that modulate the signaling output in immune defense, viral genome replication, and cell proliferation, respectively.
Ting‐Yu Wang, Jun Zhao, Ali Can Savas, Shu Zhang, Pinghui Feng   +4 more
wiley   +1 more source

A Unique Protein Self‐Assembling Nanoparticle with Significant Advantages in Vaccine Development and Production

Journal of Nanomaterials, Volume 2020, Issue 1, 2020., 2020
Nanoparticles are playing an increasingly powerful role in vaccine development. Here, we report the repurposing of nonstructural proteins 10 and 11 (hereafter NSP10) from the replicase polyprotein 1a (pp1a) of the human SARS coronavirus (severe acute respiratory syndrome) as a novel self‐assembling platform for bioengineered nanoparticles for a variety
Daniel C. Carter, Brenda Wright, W. Gray Jerome, John P. Rose, Ellen Wilson, Laura Martinez Maestro   +5 more
wiley   +1 more source

Myeloid infection links epithelial and B cell tropisms of Murid Herpesvirus-4.

PLoS Pathogens, 2012
Gamma-herpesviruses persist in lymphocytes and cause disease by driving their proliferation. Lymphocyte infection is therefore a key pathogenetic event.
Bruno Frederico, Ricardo Milho, Janet S May, Laurent Gillet, Philip G Stevenson   +4 more
doaj   +1 more source

Rhesus monkey rhadinovirus uses eph family receptors for entry into B cells and endothelial cells but not fibroblasts. [PDF]

PLoS Pathogens, 2013
Cellular Ephrin receptor tyrosine kinases (Ephrin receptors, Ephs) were found to interact efficiently with the gH/gL glycoprotein complex of the rhesus monkey rhadinovirus (RRV).
Alexander S Hahn, Ronald C Desrosiers
doaj   +1 more source

RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency

Pathogens, 2017
RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene expression upon de novo infection and reactivation from latency.
Alexis L. Santana, Darby G. Oldenburg, Varvara Kirillov, Laraib Malik, Qiwen Dong, Roman Sinayev, Kenneth B. Marcu, Douglas W. White, Laurie T. Krug   +8 more
doaj   +1 more source

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus. [PDF]

PLoS Pathogens, 2018
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human oncogenic virus associated with Kaposi's sarcoma and two B-cell malignancies. The rhesus monkey rhadinovirus (RRV) is a virus of nonhuman primates that is closely related to KSHV.
Anna K Großkopf, Armin Ensser, Frank Neipel, Doris Jungnickl, Sarah Schlagowski, Ronald C Desrosiers, Alexander S Hahn   +6 more
doaj   +1 more source

Assessment of BoHV-4-based vector vaccine intranasally administered in a hamster challenge model of lung disease

Frontiers in Immunology, 2023
IntroductionBovine herpesvirus 4 (BoHV-4) is a bovine Rhadinovirus not associated with a specific pathological lesion or disease and experimentally employed as a viral vector vaccine.
Seok-Chan Park, Laura Conti, Valentina Franceschi, Byungkwan Oh, Myeon-Sik Yang, Gaeul Ham, Antonino Di Lorenzo, Elisabetta Bolli, Federica Cavallo, Bumseok Kim, Gaetano Donofrio   +10 more
doaj   +1 more source