Results 81 to 90 of about 117,022 (301)

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Rheumatic heart disease in the setting of lupus anticoagulant antibodies without history of rheumatic fever

Journal of Rare Diseases
Background Although known cross-reactivity between molecules of β2GPI and m-protein may promote cardiac damage, the correlation between lupus anticoagulant antibodies and rheumatic heart disease is not well understood.
Lauren Morrison, Thomas Moccia
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

ACUTE RHEUMATIC FEVER IN THE XXI CENTURY: PROBLEMS AND SEARCH FOR SOLUTIONS

Медицинский совет, 2016
Acute rheumatic fever (ARF) remains a healthcare challenge. The global burden of ARF in children aged 5–14 years totals 336 thousand of new cases annually.
B. S. BELOV, N. N. KUZMINA, L. G. MEDYNTSEVA   +2 more
doaj   +1 more source

Rheumatic fever [PDF]

BMJ, 1988
H. McIntyre, S Crooks, S. S Nussey, P M Greenfield   +3 more
openaire   +2 more sources

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Prevalence of rheumatic fever and rheumatic heart disease in Bangladeshi children

Indian Heart Journal, 2015
Background: Recent prevalence data on rheumatic fever (RF) and rheumatic heart disease (RHD) are lacking in Bangladeshi population. Aim: We have done this national level cross-sectional survey to determine the prevalence of RF and RHD in Bangladeshi ...
M. Mostafa Zaman, Sohel Reza Choudhury, Shafiqur Rahman, Jasimuddin Ahmed   +3 more
doaj   +1 more source

Incidental histological diagnosis of acute rheumatic carditis: case report and review of the literature.

Frontiers in Pediatrics, 2014
Rheumatic fever remains endemic in many countries and frequently causes heart failure due to severe chronic rheumatic valvular heart disease, which requires surgical treatment.
Guilherme S. Spina, Roney O. Sampaio, Carlos Eduardo De Barros Branco, George Barreto Miranda, Vitor Emer Rosa, Flávio eTarasoutchi   +5 more
doaj   +1 more source

Review of acute rheumatic fever and rheumatic heart disease among Indigenous Australians [PDF]

This review is intended to provide an authoritative, up-to-date account of acute rheumatic fever and rheumatic heart disease among Indigenous people.PrefaceThis review of acute rheumatic fever and rheumatic heart disease among Indigenous Australians ...
Caitlin Gray, Neil Thomson
core  

Association of Childhood Acute Leukemia With Autoimmune Diseases

International Journal of Cancer, EarlyView.
A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka, Julia Ventelä, Anssi Auvinen, Olli Lohi, Atte Nikkilä   +4 more
wiley   +1 more source