Results 81 to 90 of about 375,685 (295)

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population‐Based Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit, Daphna Idan, Ariel Avraham Hasidim, Tal Michael, Amalia Levy, Gali Pariente, Eitan Lunenfeld, Sharon Daniel   +7 more
wiley   +1 more source

Rheumatic heart disease in the setting of lupus anticoagulant antibodies without history of rheumatic fever

Journal of Rare Diseases
Background Although known cross-reactivity between molecules of β2GPI and m-protein may promote cardiac damage, the correlation between lupus anticoagulant antibodies and rheumatic heart disease is not well understood.
Lauren Morrison, Thomas Moccia
doaj   +1 more source

Acute Rheumatic Fever: Findings of a Hospital-Based Study and an Overview of Reported Outbreaks

Canadian Journal of Infectious Diseases, 1990
To review the characteristics of reported outbreaks of acute rheumatic fever in the United States, and to determine if there is an increase in the incidence of acute rheumatic fever in the population served by the Hospital for Sick Children, Toronto ...
Upton D Allen, Michael Braudo, Stanley E Read   +2 more
doaj   +1 more source

Takayasu's Arteritis in a Patient with Sydenham's Chorea: Is There an Association?

Tremor and Other Hyperkinetic Movements, 2012
Background: Takayasu's arteritis (TA) has been associated with many conditions. Herein described is a case of TA in a patient with rheumatic fever complicated with Sydenham's chorea.Case Report: A 17-year-old female presented at age 6 with ...
Thiago C. Vale, Ricardo O. Maciel, Débora P. Maia, Rogério Beato, Francisco Cardoso   +4 more
doaj   +1 more source

Rheumatic fever [PDF]

BMJ, 1988
H. McIntyre, S Crooks, S. S Nussey, P M Greenfield   +3 more
openaire   +2 more sources

Longitudinal serum and CSF cytokine dynamics in NORSE: Associations with immunotherapy exposure

Epilepsia, EarlyView.
Abstract Objective To characterize serum and cerebrospinal fluid (CSF) cytokine dynamics according to immunotherapy exposure in cryptogenic new‐onset refractory status epilepticus (cNORSE). Methods We analyzed cytokine profiles in 94 serum and 42 CSF samples from 29 and 14 patients, respectively, with cNORSE.
Aurélie Hanin, Clémence Marois, Léa Cosme, Quentin Calonge, Zineb Hayatou, Sarah Baer, Anna‐Lena Behr, Simone Beretta, Francesca Bisulli, Serena Broggi, Michael Cardinale, Carlos Castillo‐Pinto, Adam Celier, Thomas Coppens, Anne De Saint Martin, Krista Eschbach, Susana Ferrao Santos, Elizabeth E. Gerard, Teneille Gofton, Margaret T. Gopaul, Karnig Kazazian, Jeroen Kerstens, Humberto L. Moser Filho, Lorenzo Muccioli, Roberto Santalucia, Hannah Stamberger, Eyal Muscal, Lawrence J. Hirsch, Sophie Demeret, Vincent Navarro   +29 more
wiley   +1 more source

Rheumatic Fever: Natural History and Treatment [PDF]

, 1965
Major advances in clinical and laboratory research methods have significantly clarified the identification and natural course of rheumatic fever in the past two ...
Feinstein, Alvan R.
core  

Annona squamosa: Phytochemical Fingerprinting, Health‐Improving Traits, and Functional Applications

Food Chemistry International, EarlyView.
Annona squamosa (custard apple) is a nutrient‐rich fruit containing diverse bioactive phytochemicals (e.g., acetogenins, flavonoids, and alkaloids) that contribute to multiple health benefits, including antioxidant, antihyperlipidemic, and antimicrobial activities, highlighting its potential as a functional food and medicinal resource.
Mohamed Fawzy Ramadan, Jumanah Reda Kurdi, Manar Yahya Alzahrani, Asmaa Ibrahim Alshaikhi, Jumanah Samir Hazzazi   +4 more
wiley   +1 more source

ACUTE RHEUMATIC FEVER IN THE XXI CENTURY: PROBLEMS AND SEARCH FOR SOLUTIONS

Медицинский совет, 2016
Acute rheumatic fever (ARF) remains a healthcare challenge. The global burden of ARF in children aged 5–14 years totals 336 thousand of new cases annually.
B. S. BELOV, N. N. KUZMINA, L. G. MEDYNTSEVA   +2 more
doaj   +1 more source