Results 131 to 140 of about 927,717 (352)

AGAPIR: A Novel PIWI‐Interacting RNA Enhancing Post‐Decompression Angiogenesis in Degenerative Cervical Myelopathy

open access: yesAdvanced Science, EarlyView.
The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie   +8 more
wiley   +1 more source

Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical Considerations

open access: yesCurrent Treatment Options in Cardiovascular Medicine, 2017
Opinion statementEarly recognition of group A streptococcal pharyngitis and appropriate management with benzathine penicillin using local clinical prediction rules together with validated rapi-strep testing when available should be incorporated in ...
L. Zühlke   +12 more
semanticscholar   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

open access: yesAdvanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li   +8 more
wiley   +1 more source

A predominance of hypertensive heart disease among patients with cardiac disease in Buea, a semi-urban setting, South West Region of Cameroon

open access: yesBMC Research Notes, 2017
Objective The pattern of heart disease is diverse within and among world regions. The little data on the spectrum of heart disease in Cameroon has been so far limited to major cities.
Clovis Nkoke   +6 more
doaj   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

open access: yesAdvanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu   +5 more
wiley   +1 more source

AWARENESS OF RHEUMATIC HEART DISEASE IN PATIENTS SUFFERING FROM RHEUMATIC HEART DISEASE

open access: yesJournal of University Medical & Dental College, 2016
: OBJECTIVE: To determine the degree of awareness about the different aspects of rheumatic heart disease in patients coming to different departments of Faisalabad Institute of Cardiology, Faisalabad. STUDY DESIGN AND DURATION: Questionnaire based survey
M Hamid Saeed1, Muhammad Shahzad Afzal
doaj  

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