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Lancet, The, 2016 Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Josef S Smolen, Daniel Aletaha
exaly +9 more sources
Nature Immunology, 2019 To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts
Fan Zhang, Kevin Wei, Kamil Slowikowski
exaly +2 more sources
Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
Nature Reviews Rheumatology, 2020 Gary S Firestein
exaly +2 more sources
The immunology of rheumatoid arthritis
Nature Immunology, 2020 Cornelia M Weyand, Jörg J Goronzy
exaly +2 more sources
Inflammation and Regeneration, 2020 AbstractRheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinical symptoms including pain, swelling, stiffness of multiple joints, fever, and malaise. Joint destruction progresses soon after the onset,
Primdahl, Jette, Esbensen, Bente Appel
openaire +5 more sources
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Nature, 2017 Deepak A Rao +2 more
exaly +2 more sources
Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis.
New England Journal of Medicine, 2022 BACKGROUND Increases in lipid levels and cancers with tofacitinib prompted a trial of major adverse cardiovascular events (MACE) and cancers in patients with rheumatoid arthritis receiving tofacitinib as compared with a tumor necrosis factor (TNF ...
S. Ytterberg +12 more
semanticscholar +1 more source
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Nature, 2023 Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction^ 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, suggesting an undefined ...
Fan Zhang +51 more
semanticscholar +1 more source
Arthritis Research & Therapy, 2023 Purpose We aimed to explore the relationship between the systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018. Methods We collected data from the NHANES database from 1999 to 2018.
Bo Liu +4 more
semanticscholar +1 more source