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Rheumatoid arthritis [PDF]

Lancet, The, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Josef S Smolen, Daniel Aletaha
exaly   +7 more sources

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018 [PDF]

Arthritis Research & Therapy, 2023
Purpose We aimed to explore the relationship between the systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018. Methods We collected data from the NHANES database from 1999 to 2018.
Bo Liu, Jie Wang, Yanyan Li, Kangpeng Li, Qiang Zhang   +4 more
openalex   +2 more sources

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Nature Immunology, 2019
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts
Fan Zhang, Kevin Wei, Kamil Slowikowski
exaly   +2 more sources

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

Nature Reviews Rheumatology, 2020
Gary S Firestein
exaly   +2 more sources

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis.

New England Journal of Medicine, 2022
BACKGROUND Increases in lipid levels and cancers with tofacitinib prompted a trial of major adverse cardiovascular events (MACE) and cancers in patients with rheumatoid arthritis receiving tofacitinib as compared with a tumor necrosis factor (TNF ...
S. Ytterberg, Deepak L. Bhatt, T. Mikuls, G. Koch, R. Fleischmann, J. Rivas, R. Germino, S. Menon, Yanhu Sun, Cunshan Wang, Andrea Shapiro, K. Kanik, C. Connell   +12 more
semanticscholar   +1 more source

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

Nature, 2023
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction^ 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, suggesting an undefined ...
Fan Zhang, A. Jonsson, A. Nathan, N. Millard, Michelle Curtis, Qian Xiao, M. Gutierrez-Arcelus, W. Apruzzese, G. Watts, Dana Weisenfeld, S. Nayar, J. Rangel-Moreno, Nida Meednu, K. Marks, I. Mantel, Joyce B. Kang, Laurie Rumker, Joseph R. Mears, Kamil Slowikowski, Kathryn Weinand, D. Orange, L. Geraldino‐Pardilla, K. Deane, Darren Tabechian, Arnoldas Ceponis, G. Firestein, M. Maybury, I. Sahbudin, A. Ben-Artzi, A. Mandelin, A. Nerviani, M. Lewis, F. Rivellese, C. Pitzalis, Laura B. Hughes, Diane Horowitz, E. DiCarlo, E. Gravallese, Brendan F Boyce, Larry W. Moreland, S. Goodman, Harris Perlman, V. Holers, K. Liao, A. Filer, Vivian P. Bykerk, Kevin Wei, Deepak A. Rao, L. Donlin, J. Anolik, Michael B. Brenner, Soumya Raychaudhuri   +51 more
semanticscholar   +1 more source

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Nature, 2017
Deepak A Rao, Michael F Gurish, Jennifer L Marshall   +2 more
exaly   +2 more sources

Angiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis

Experimental and Molecular Medicine, 2023
Spondyloarthritis (SpA) is a chronic inflammatory disease that results in bone ankylosis. The tissue renin-angiotensin system (RAS) is an emerging pathway potentially implicated in SpA-associated bone changes.
Jin Sun Choi, Ji-Young Kim, Min-Joo Ahn, Hanbit Jang, Seungtaek Song, Sung Hoon Choi, Ye-Soo Park, Sungsin Jo, Tae-Hwan Kim, Seung Cheol Shim   +9 more
doaj   +1 more source

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

Arthritis & Rheumatology, 2021
To develop updated guidelines for the pharmacologic management of rheumatoid arthritis.
L. Fraenkel, J. Bathon, B. England, E. St. Clair, T. Arayssi, Kristine Carandang, K. Deane, M. Genovese, K. Huston, G. Kerr, J. Kremer, Mary C. Nakamura, L. Russell, Jasvinder A. Singh, Benjamin J. Smith, J. Sparks, S. Venkatachalam, M. Weinblatt, Mounir Al-Gibbawi, J. Baker, K. Barbour, J. Barton, L. Cappelli, Fatimah Chamseddine, M. George, S. Johnson, Lara A. Kahale, Basil S. Karam, A. Khamis, I. Navarro-Millán, R. Mirza, P. Schwab, Namrata Singh, Marat Turgunbaev, Amy S. Turner, Sally Yaacoub, E. Akl   +36 more
semanticscholar   +1 more source

The association between comorbidities and disease activity in patients with rheumatoid arthritis: a multicenter, cross-sectional cohort study in Japan with the highest proportion of elderly individuals

Egyptian Rheumatology and Rehabilitation, 2022
Background This study aimed to assess the association of disease activity with the presence of comorbidities in patients with rheumatoid arthritis, using the Akita Orthopedic Group on Rheumatoid Arthritis (AORA) registry, a multicenter, cross-sectional ...
Takanori Miura, Naohisa Miyakoshi, Takeshi Kashiwagura, Hiroyuki Tsuchie, Yusuke Sugimura, Yoichi Shimada   +5 more
doaj   +1 more source