Results 141 to 150 of about 131,345 (205)

Rheumatoid Arthritis [PDF]

BMJ, 1938
openaire   +2 more sources

Cuproptosis Signature Would Reveal the Acute‐Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
Neuromyelitis optica spectrum disorder (NMOSD) has distinct acute‐remitting courses but lacks biomarkers for predicting relapse. Recent studies found cuproptosis‐related genes affect its course, and a model built accordingly can predict relapse to aid intervention.
Peidong Liu, Ruoyu Li, Xinlin Wang, Hui Li, Huiru Hu, Ang Shen, Wenping Zhu, Jiali Pan, Yanmeng Xing, Weiming Xia, Henan Jiao, Di Chen, Lixin Wu, Li Liu, Ju Liu, Bin Yu, Xianzhi Liu, Hongbo Liu   +17 more
wiley   +1 more source

Placebos in the Treatment of Rheumatoid Arthritis and other Rheumatic Conditions

, 1957
Eugene F. Traut, E Passarelli
openalex   +1 more source

A Compartmentalized Joint‐on‐chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
A compartmentalized joint‐on‐chip (JoC) platform is here developed, modelling the interactions between cartilage and synovium in osteoarthritis (OA). Using independent culture and mechanical/biochemical stimulation, the JoC revealed how inflammation and mechanical damage drive mutual tissue changes.
Cecilia Palma, Shima Salehi, Michela Anna Polidoro, Matteo Moretti, Marco Rasponi, Silvia Lopa, Paola Occhetta   +6 more
wiley   +1 more source

Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting

Advanced Science, EarlyView.
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang, Rongmao Qiu, Yongjie Huang, Yinghua Liu, Kui Huang, Suwen Zhao, Yang Li   +6 more
wiley   +1 more source

CellPhenoX: An Explainable Machine Learning Method for Identifying Cell Phenotypes To Predict Clinical Outcomes from Single‐Cell Multi‐Omics

Advanced Science, EarlyView.
CellPhenoX is an explainable machine learning framework that identifies cell‐specific phenotypes and interaction effects from single‐cell omics data. By leveraging interpretable models, it enables robust discovery of cell‐level phenotypes that contribute to clinical outcomes.
Jade Young, Jun Inamo, Zachary Caterer, Revanth Krishna, Fan Zhang   +4 more
wiley   +1 more source

Rheumatoid Arthritis [PDF]

BMJ, 1911
openaire   +2 more sources

Personalized Medication for Chronic Diseases Using Multimodal Data‐Driven Chain‐of‐Decisions

Advanced Science, EarlyView.
A MDD‐CoD is proposed for personalized chronic disease medication. The framework simulates clinical chain‐of‐decisions through three linked deep learning tasks, validated on multi‐center datasets (3 hospitals, 4 diseases), demonstrating enhanced generalization and interpretability in cross‐disease applications.
Xiaoli Chu, Yiheng Ye, Siqiao Tang, Miaoru Han, Guowei Wang, Shuai Lin, Bingzhen Sun, Qingchun Huang, Yan Zhang, Xiaodong Chu, Kun Bao   +10 more
wiley   +1 more source

AGAPIR: A Novel PIWI‐Interacting RNA Enhancing Post‐Decompression Angiogenesis in Degenerative Cervical Myelopathy

Advanced Science, EarlyView.
The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie, Yiling Peng, Tianyu Qin, Cuimei Chen, Zhenxiao Ren, Naibo Feng, Chungeng Liu, Songlin Peng, Houqing Long   +8 more
wiley   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source