Results 21 to 30 of about 1,164,546 (387)

Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis

International Journal of Molecular Sciences, 2021
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation causing progressive joint damage that can lead to lifelong disability. The pathogenesis of RA involves a complex network of various cytokines and cells that
N. Kondo, T. Kuroda, D. Kobayashi
semanticscholar   +1 more source

Rheumatoid arthritis [PDF]

Inflammation and Regeneration, 2020
AbstractRheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinical symptoms including pain, swelling, stiffness of multiple joints, fever, and malaise. Joint destruction progresses soon after the onset,
openaire   +3 more sources

Non-TNF inhibitor switchers versus TNF inhibitor cyclers from multicentre rheumatoid arthritis ultrasonography prospective cohort in Japan

Immunological Medicine, 2020
To compare therapeutic efficacy of tumour necrosis factor inhibitor (TNFi) cyclers and non-TNFi switchers in patients with rheumatoid arthritis (RA) having inadequate response to previous TNFis (TNF-IR patients) using composite measures including imaging
Yushiro Endo, Shin-ya Kawashiri, Shimpei Morimoto, Ayako Nishino, Momoko Okamoto, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Tamami Yoshitama, Nobutaka Eiraku, Naoki Matsuoka, Akitomo Okada, Keita Fujikawa, Hiroaki Hamada, Tomomi Tsuru, Shuji Nagano, Yojiro Arinobu, Toshihiko Hidaka, Yoshifumi Tada, Atsushi Kawakami   +28 more
doaj   +1 more source

Prevalence of Sexual Disorders in Patients With Rheumatoid Arthritis and Associated Factors

Sexual Medicine, 2020
Introduction: Rheumatoid arthritis (RA) is a chronic and progressive pathology, present in between 0.5% and 1% of adults. Sexual disorders (SDs) occur in between 31% and 70% of all patients with RA.
Pedro Santos-Moreno, MD, MSc, Carlos Alberto Castro, MD, MSc, Laura Villarreal, MSc, Diana Buitrago, MSc   +3 more
doaj   +1 more source

Clinical analyses of ultrasound-guided nerve block in lower-extremity surgery: A retrospective study

Journal of Orthopaedic Surgery, 2021
Purpose: The purpose of this study is to examine the clinical effects and results of lower-extremity surgery under ultrasound-guided nerve block; time required for nerve block, anesthesia onset time, duration of anesthesia, duration of analgesia ...
Chan Kang, Deuk-Soo Hwang, Jae-Hwang Song, Gi-Soo Lee, Jeong-Kil Lee, Sung-Jin Hwang, Je-Hyung Jeon, Byung-Kuk An   +7 more
doaj   +1 more source

Downregulation of Tumour Necrosis Factor α Gene Expression in Peripheral Blood Mononuclear Cells Cultured in the Presence of Tofacitinib Prior to Therapy Is Associated with Clinical Remission in Patients with Rheumatoid Arthritis

Current Issues in Molecular Biology, 2022
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by pain, synovial hyperplasia, mononuclear cell infiltration, bone erosion and joint destruction.
Elena V. Tchetina, Galina A. Markova, Azamat M. Satybaldyev, Aleksandr M. Lila   +3 more
doaj   +1 more source

Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis

STAR Protocols, 2022
Summary: By their capacity to induce peripheral T cell tolerance, dendritic cells (DCs) present a promising target cell and therapeutic strategy for treatment of several autoimmune diseases including multiple sclerosis (MS).
Andrea Vogel, Martina Kerndl, Gernot Schabbauer, Omar Sharif   +3 more
doaj   +1 more source

A protocol for a randomised controlled trial of prefabricated versus customised foot orthoses for people with rheumatoid arthritis: the FOCOS RA trial [Foot Orthoses – Customised v Off-the-Shelf in Rheumatoid Arthritis] [PDF]

, 2018
Background Foot pain is common in rheumatoid arthritis and appears to persist despite modern day medical management. Several clinical practice guidelines currently recommend the use of foot orthoses for the treatment of foot pain in people with ...
Gallagher, Kellie S., Godwin, Jon, Hendry, Gordon J., Steultjens, Martijn, Woodburn, James   +4 more
core   +1 more source

Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions

Annals of the Rheumatic Diseases, 2012
Background Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ...
J. Smolen, M. Schoels, Norihiro Nishimoto, F. C. Breedveld, G. Burmester, M. Dougados, P. Emery, G. Ferraccioli, C. Gabay, A. Gibofsky, J. Gómez-Reino, Graeme Jones, T. Kvien, M. Murakami, N. Betteridge, Clifton Bingham, Vivian Bykerk, Ernest Choy, B. Combe, Maurizio Cutolo, W. Graninger, Angel Lanas, Emilio Martín-Mola, C. Montecucco, Mikkel Ostergaard, K. Pavelka, A. Rubbert-Roth, N. Sattar, M. Scholte-Voshaar, Yoshiya Tanaka, Michael Trauner, Gabriele Valentini, Kevin L Winthrop, M. de Wit, D. van der Heijde   +34 more
semanticscholar   +1 more source

Persistencia de medicamentos biológicos durante ocho años en pacientes con artritis reumatoide y espondiloartritis [PDF]

, 2019
Objective: To calculate the persistence, over a period of eight years, the retention rate of first and second-line of treatment with biological agents in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis and to compare ...
Balsa, Alejandro, González-Fernández, María, Herrero, Alicia, Jiménez-Nácher, Inmaculada, Moreno, Francisco, Villamañán, Elena   +5 more
core   +3 more sources