Frontiers in Immunology, 2018 ObjectiveDendritic cells (DCs) are key orchestrators of immune function. To date, rheumatoid arthritis (RA) researchers have predominantly focused on a potential pathogenic role for CD1c+ DCs.
Faye A. H. Cooles +15 more
doaj +1 more source
Quantitative predictive modelling approaches to understanding rheumatoid arthritis: A brief review [PDF]
, 2019 Rheumatoid arthritis is a chronic autoimmune disease that is a major public health challenge. The disease is characterised by inflammation of synovial joints and cartilage erosion, which leads to chronic pain, poor life quality and, in some cases, premature mortality.
arxiv +1 more source
Employing Feature Selection Algorithms to Determine the Immune State of a Mouse Model of Rheumatoid Arthritis [PDF]
arXiv, 2022 The immune response is a dynamic process by which the body determines whether an antigen is self or nonself. The state of this dynamic process is defined by the relative balance and population of inflammatory and regulatory actors which comprise this decision making process. The goal of immunotherapy as applied to, e.g. Rheumatoid Arthritis (RA), then,
arxiv
Estimation of age-specific excess mortality of men and women with rheumatoid arthritis (RA) in Germany [PDF]
arXiv, 2023 A MCMC approach is used to estimate the age-specific mortality rate ratio for German men and women with RA. For constructing priors, we calculate a range of admissible values from prevalence and incidence data based on about 60 million people in Germany.
arxiv
Baillière's Clinical Rheumatology, 1988 The results of family and twin studies suggest that RA may result from an interaction between an oligogenic susceptibility and unknown environmental factors. Part of this genetic predisposition is accounted for by genes within the MHC where there is a well-documented association with HLA-DR4.
D M, Grennan, P A, Sanders
openaire +4 more sources
Comparison of the Belgian Rheumatoid Arthritis Disability Assessment and Health Assessment Questionnaires as Tools to Predict the Need for Support Measures in Patients with Rheumatoid Arthritis. [PDF]
PLoS ONE, 2016 OBJECTIVE:Scores on the Health Assessment Questionnaire (HAQ) predict the need for support measures in patients with rheumatoid arthritis (RA). In this study we compare the performance of the HAQ in this context with that of the more disease-specific ...
Xavier Janssens +3 more
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Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)--positive rheumatoid arthritis in three Asian ethnic groups. [PDF]
PLoS ONE, 2011 BACKGROUND: To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia.
Too Chun-Lai +10 more
doaj +1 more source
Prediction of drug effectiveness in rheumatoid arthritis patients based on machine learning algorithms [PDF]
arXiv, 2022 Rheumatoid arthritis (RA) is an autoimmune condition caused when patients' immune system mistakenly targets their own tissue. Machine learning (ML) has the potential to identify patterns in patient electronic health records (EHR) to forecast the best clinical treatment to improve patient outcomes.
arxiv
Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis [PDF]
J Autoimmun. 2017 Nov; 84:29-45, 2017 Oxidation-associated malondialdehyde (MDA) modification of proteins can generate immunogenic neo-epitopes that are recognized by autoantibodies. In health, IgM antibodies to MDA-adducts are part of the natural antibody pool, while elevated levels of IgG anti-MDA are associated with inflammatory conditions.
arxiv +1 more source