Results 31 to 40 of about 77,402 (234)

Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19

Nature Communications, 2023
Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely ...
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Rückert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O’Mahony, Marek Jutel, Tatiana Kebadze, David J. Jackson, Michael R. Edwards, Volker Thiel, Sebastian L. Johnston, Cezmi A. Akdis, Milena Sokolowska   +24 more
doaj   +1 more source

Defining critical roles for NF‐κB p65 and type I interferon in innate immunity to rhinovirus

EMBO Molecular Medicine, 2012
The importance of NF‐κB activation and deficient anti‐viral interferon induction in the pathogenesis of rhinovirus‐induced asthma exacerbations is poorly understood.
Nathan W. Bartlett, Louise Slater, Nicholas Glanville, Jennifer J. Haas, Gaetano Caramori, Paolo Casolari, Deborah L. Clarke, Simon D. Message, Julia Aniscenko, Tatiana Kebadze, Jie Zhu, Patrick Mallia, Joseph P. Mizgerd, Maria Belvisi, Alberto Papi, Sergei V. Kotenko, Sebastian L. Johnston, Michael R. Edwards   +17 more
doaj   +1 more source

Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice.

PLoS ONE, 2014
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigating rhinovirus-induced exacerbation of allergic airways disease have employed systemic sensitisation/intranasal challenge with ovalbumin.
Jennifer A Phan, Anthony Kicic, Luke J Berry, Lynette B Fernandes, Graeme R Zosky, Peter D Sly, Alexander N Larcombe   +6 more
doaj   +1 more source

Sensor recorded changes in rates of hand washing with soap in response to the media reports of the H1N1 pandemic in Britain [PDF]

, 2011
Peer ...
Aunger, R., Curtis, V., De Barra, M., Fleischman, Diana, Judah, G., Webster, G.   +5 more
core   +4 more sources

Population structure and evolution of Rhinoviruses.

PLoS ONE, 2014
Rhinoviruses, formerly known as Human rhinoviruses, are the most common cause of air-borne upper respiratory tract infections in humans. Rhinoviruses belong to the family Picornaviridae and are divided into three species namely, Rhinovirus A, -B and -C ...
Vaishali P Waman, Pandurang S Kolekar, Mohan M Kale, Urmila Kulkarni-Kale   +3 more
doaj   +1 more source

Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication

Nature Communications, 2022
Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou, Joshi Ramanjulu, Lee M. Booty, Gisela Jimenez-Duran, Hakan Keles, Ken Saunders, Neysa Nevins, Emma Koppe, Louise K. Modis, G. Scott Pesiridis, John Bertin, Kathy Triantafilou   +11 more
doaj   +1 more source

Mechanism of Rhinovirus Immunity and Asthma

Frontiers in Immunology, 2021
The majority of asthma exacerbations in children are caused by Rhinovirus (RV), a positive sense single stranded RNA virus of the Picornavirus family.
Zuqin Yang, Hannah Mitländer, Tytti Vuorinen, Susetta Finotto   +3 more
doaj   +1 more source

Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions

Frontiers in Allergy
Rhinovirus is a widespread virus associated with several respiratory diseases, especially asthma exacerbation. Currently, there are no accurate therapies for rhinovirus. Encouragingly, it is found that during rhinovirus-induced immunoreactions the levels
Le Sang, Xia Gong, Yunlei Huang, Linling Zhang, Jian Sun   +4 more
doaj   +1 more source

Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma.

PLoS ONE, 2017
Rhinovirus infection is associated with the majority of asthma exacerbations. The role of fractalkine in anti-viral (type 1) and pathogenic (type 2) responses to rhinovirus infection in allergic asthma is unknown.
Nadine Upton, David J Jackson, Alexandra A Nikonova, Suzie Hingley-Wilson, Musa Khaitov, Ajerico Del Rosario, Stephanie Traub, Maria-Belen Trujillo-Torralbo, Max Habibi, Sarah L Elkin, Onn M Kon, Michael R Edwards, Patrick Mallia, Joseph Footitt, Jonathan Macintyre, Luminita A Stanciu, Sebastian L Johnston, Annemarie Sykes   +17 more
doaj   +1 more source

Rhinovirus chemotherapy

Antiviral Research, 2006
Human rhinoviruses (HRV), members of the Picornaviridae family, are comprised of over 100 different virus serotypes. HRV represent the single most important etiological agents of the common cold [Arruda, E., Pitkaranta, A., Witek Jr., T.J., Doyle, C.A., Hayden, F.G., 1997.
openaire   +2 more sources