Results 51 to 60 of about 31,404 (177)

Isolation of a Bovine Rhinovirus

Experimental Biology and Medicine, 1968
SummaryA bovine rhinovirus was isolated from an apparently normal calf in BEK cell cultures. The virus was found to contain RNA, was 25-27 mμ in diameter, acid labile, chloroform resistant, and was stabilized against thermal inactivation by molar MgCl2. The virus grew slightly better in 33°C than at 37°C. The virus was serologically related to 2 German
Mary G. Lillie, Sashi B. Mohanty
openaire   +2 more sources

Clinical features of rhinovirus infection in hospitalized adult patients during the epidemic season 2017–2018

Журнал инфектологии, 2020
Purpose. Rhinovirus infection has in the past been perceived as a disease capable of causing mild respiratory symptoms in most cases in children. Modern clinical and epidemiological studies have shown that rhinovirus infection in adults and children and ...
M. A. Bichurina, L. V. Voloshchuk, A. Go, M. M. Pisareva, D. A. Guzhov   +4 more
doaj   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Neonatal immune response to rhinovirus A16 has diminished dendritic cell function and increased B cell activation. [PDF]

PLoS ONE, 2017
BACKGROUND:Rhinovirus infections during infancy account for the majority of respiratory illness health care utilization and are an associated risk factor for subsequent development of allergic asthma.
Amanda Barlow-Anacker, Yury Bochkov, James Gern, Christine M Seroogy   +3 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

Exploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang, Maike Zheng, Yun Zhang, Yu Xue, Sibo Long, Chaohong Wang, Qing Sun, Jun Yan, Yiheng Shi, Bin Yang, Shang Ma, Tiantian Zhang, Lei Cao, Yan Chen, Wenfu Ju, Jing Zhang, Yan Zhao, Mengqiu Gao, Laurence Don Wai Luu, Xinting Yang, Guirong Wang   +20 more
wiley   +1 more source

Rhinovirus Biology, Antigenic Diversity, and Advancements in the Design of a Human Rhinovirus Vaccine [PDF]

Frontiers in Microbiology, 2017
Human rhinovirus (HRV) remains a leading cause of several human diseases including the common cold. Despite considerable research over the last 60 years, development of an effective vaccine to HRV has been viewed by many as unfeasible due, in part, to the antigenic diversity of circulating HRVs in nature.
Christopher C. Stobart, Jenna M. Nosek, Martin L. Moore, Martin L. Moore   +3 more
openaire   +3 more sources

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis

Virology Journal, 2022
Background Rhinovirus is a common viral aetiology of upper respiratory infection and is mostly associated with common cold or flu-like illness. Although rhinovirus has been recognized as a pathogen for lower respiratory infections in severe cases ...
Jun Liu, Hongwei Zhao, Ziheng Feng, Yingchao Liu, Qianyu Feng, Suyun Qian, Lili Xu, Hengmiao Gao, Zhengde Xie   +8 more
doaj   +1 more source

Clinical characteristics and risk factors of severe bocavirus‐positive pneumonia in children and a literature review

Pediatric Discovery, EarlyView.
The study explored the clinical characteristics and risk factors of HBoV‐positive severe pneumonia in children. These findings indicate that HBoV can be identified in respiratory samples from children with severe pneumonia, denoting its role as a viral pathogen in hospitalized children with this condition.
Jing Liao, Zhongying Yang, Yu He, Jianhua Wei, Luo Ren, Enmei Liu, Na Zang   +6 more
wiley   +1 more source

Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A71 Challenge

Phytotherapy Research, EarlyView.
Pterostilbene (Pte) binds to the VP1 hydrophobic pocket of enteroviruses, stabilizing the viral capsid and preventing uncoating and RNA release. In vitro, Pte inactivates virions and impairs viral attachment, entry, and replication. In vivo, oral administration of Pte in hSCARB2‐transgenic mice reduces clinical symptoms and improves survival ...
Kuan‐Ting Chuang, Siao‐Cian Pan, Bor‐Luen Chiang, Shih‐Hsun Chen, Min‐Hsiung Pan, Yu‐Li Chen, Cheng‐Sheng Lin, Chun‐Kai Pan, Jing‐Yi Lin, Yu‐Li Lin   +9 more
wiley   +1 more source