Rho factor mediates flagellum and toxin phase variation and impacts virulence in Clostridioides difficile. [PDF]
PLoS Pathogens, 2020 The intestinal pathogen Clostridioides difficile exhibits heterogeneity in motility and toxin production. This phenotypic heterogeneity is achieved through phase variation by site-specific recombination via the DNA recombinase RecV, which reversibly ...
Dominika Trzilova +3 more
doaj +2 more sources
Exploratory Associations of Inflammatory Cytokines, Brain-Derived Neurotrophic Factor, and Vascular Endothelial Growth Factor with Clinical Outcomes in Patients with Bipolar Disorder [PDF]
MetabolitesBackground/Objectives: Bipolar disorder is characterized by psychosocial dysfunction, cognitive impairment, and incomplete recovery. Although inflammatory and neurotrophic mechanisms have been implicated, their relationships with multidimensional ...
Fumito Hamada +9 more
doaj +2 more sources
Scambio, a novel guanine nucleotide exchange factor for Rho
Molecular Cancer, 2004 Background Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis.
Groffen John +5 more
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iScience, 2022 Summary: The conjugative pilus expression (Cpx) stress response system can sense cell envelope stressors, such as misfolded proteins, and upregulate proteases to modify or degrade damaged proteins.
Biying Wang +6 more
doaj +1 more source
Thrombopoietin and collagen in low doses cooperatively induce human platelet activation
Acute Medicine & Surgery, 2022 Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to ...
Tomoaki Doi +13 more
doaj +1 more source
Mycobacterium tuberculosis Rho is an NTPase with distinct kinetic properties and a novel RNA-binding subdomain. [PDF]
PLoS ONE, 2014 Two mechanisms--factor independent and dependent termination--ensure the completion of RNA synthesis in eubacteria. Factor-dependent mechanism relies on the Rho protein to terminate transcription by interacting with RNA polymerase.
Anirban Mitra +2 more
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Mechanochemistry of Transcription Termination Factor Rho [PDF]
Molecular Cell, 2006 Rho is a ring-shaped hexameric motor protein that translocates along nascent mRNA transcript and terminates transcription of select genes in bacteria. Using a numerical optimization algorithm that simultaneously fits all of the presteady-state ATPase kinetic data, we determine how Rho utilizes the chemical energy of ATP hydrolysis to translocate RNA. A
Adelman, Joshua L. +6 more
openaire +2 more sources
Zanco Journal of Medical Sciences, 2021 Background and objective: Oral mucositis is caused by the destruction of the oral mucosal epithelium and suppression of its growth secondary to antineoplastic treatment in the form of chemotherapeutic drugs, substances, or radiotherapy.
Hayder Fakhir Mohammad +4 more
doaj +1 more source
Termination factor Rho: From the control of pervasive transcription to cell fate determination in Bacillus subtilis. [PDF]
PLoS Genetics, 2017 In eukaryotes, RNA species originating from pervasive transcription are regulators of various cellular processes, from the expression of individual genes to the control of cellular development and oncogenesis.
Vladimir Bidnenko +10 more
doaj +1 more source
Rho-dependent transcription termination proceeds via three routes
Nature Communications, 2022 Rho is a general transcription termination factor in bacteria. Here, Song et al. use single-molecule fluorescence assays to provide evidence that Rho-mediated transcription termination can occur via three kinetically different routes.
Eunho Song +7 more
doaj +1 more source