Results 21 to 30 of about 161,318 (264)

Termination factor Rho mediates transcriptional reprogramming of Bacillus subtilis stationary phase.

open access: yesPLoS Genetics, 2023
Transcription termination factor Rho is known for its ubiquitous role in suppression of pervasive, mostly antisense, transcription. In the model Gram-positive bacterium Bacillus subtilis, de-repression of pervasive transcription by inactivation of rho ...
Vladimir Bidnenko   +8 more
doaj   +1 more source

Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization

open access: yeseLife, 2021
Actomyosin contractility is regulated by Rho-GTP in cell migration, cytokinesis and morphogenesis in embryo development. Whereas Rho activation by Rho-GTP exchange factor (GEF), RhoGEF2, is well known in actomyosin contractility during cytokinesis at the
Swati Sharma, Richa Rikhy
doaj   +1 more source

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro.

open access: yesPLoS ONE, 2023
Obscurin is a giant muscle protein (>800 kDa) featuring multiple signalling domains, including an SH3-DH-PH domain triplet from the Trio-subfamily of guanosine nucleotide exchange factors (GEFs).
Daniel Koch   +8 more
doaj   +3 more sources

Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction

open access: yesRespiratory Research, 2005
Background In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction.
Zaagsma Johan   +5 more
doaj   +1 more source

Rho Factor: Transcription Termination in Four Steps [PDF]

open access: yesCurrent Biology, 2003
Rho factor is a hexameric ring-shaped helicase which terminates transcription in Escherichia coli. Two recent crystal structures of Rho in complex with nucleic acid reveal how this helicase ring loads onto mRNA and encircles it.
Kaplan, Daniel L., O'Donnell, Mike
openaire   +2 more sources

Basic quantum subroutines: finding multiple marked elements and summing numbers [PDF]

open access: yesQuantum
We show how to find all $k$ marked elements in a list of size $N$ using the optimal number $O(\sqrt{N k})$ of quantum queries and only a polylogarithmic overhead in the gate complexity, in the setting where one has a small quantum memory.
Joran van Apeldoorn   +2 more
doaj   +1 more source

Principles that govern competition or co-existence in Rho-GTPase driven polarization. [PDF]

open access: yesPLoS Computational Biology, 2018
Rho-GTPases are master regulators of polarity establishment and cell morphology. Positive feedback enables concentration of Rho-GTPases into clusters at the cell cortex, from where they regulate the cytoskeleton.
Jian-Geng Chiou   +5 more
doaj   +1 more source

Activation of STAT transcription factors by the Rho-family GTPases [PDF]

open access: yesBiochemical Society Transactions, 2020
The Rho-family of small GTPases are biological molecular switches that are best known for their regulation of the actin cytoskeleton. Through their activation and stimulation of downstream effectors, the Rho-family control pathways involved in cellular morphology, which are commonly activated in cancer cell invasion and metastasis.
Jessica Corry   +2 more
openaire   +2 more sources

Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury: Renoprotective Effect of Rho-Kinase Inhibitor in Hypertensive Glomerulosclerosis

open access: yesJournal of Pharmacological Sciences, 2006
.: Among the GTP-binding proteins, Rho is known to function as a molecular switch in various cellular functions. Among the Rho effectors, the cellular function and signal transduction of Rho-kinase have been extensively studied.
Toshio Nishikimi, Hiroaki Matsuoka
doaj   +1 more source

Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation

open access: yesTherapeutic Advances in Respiratory Disease, 2020
Background and aims: Expansion and morphological dysregulation of the bronchial vascular network occurs in asthmatic airways. Interleukin (IL) -17 and Rho-kinase (ROCK) are known to act in inflammation control and remodeling.
Tabata M. dos Santos   +10 more
doaj   +1 more source

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