Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis
Journal of Research in Medical Sciences, 2010 Cellular and molecular pathways link thrombosis and innate immune system during sepsis. Extrinsic pathway activation of protease thrombin through FVIIa and tissue factor (TF) in sepsis help activate its endothelial cell (EC) membrane Protease Activated ...
Filip A Konecny
doaj
Genome-Wide Analysis of Gene and Protein Expression of Dysplastic Naevus Cells
Journal of Skin Cancer, 2012 Cutaneous melanoma, a type of skin tumor originating from melanocytes, often develops from premalignant naevoid lesions via a gradual transformation process driven by an accumulation of (epi)genetic lesions.
Linda Gao +7 more
doaj +1 more source
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1); Rho GDP dissociation inhibitor (GDI)-α (ARHGDIA) [PDF]
, 2008 openalex +1 more source
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1; RAC1) [PDF]
, 2012 openalex +1 more source
Phosphatidylserine polarization is required for proper Cdc42 localization and for development of cell polarity. [PDF]
, 2010 We used genetically-encoded fluorescent probes to visualize the distribution of phosphatidylserine (PS) in live S. cerevisiae. The majority of the PS was found to reside in the cytosolic leaflet of the plasma membrane.
Gregory Fairn, Sergio Grinstein
core +1 more source
The Role of Mg2+ Cofactor in the Guanine Nucleotide Exchange and GTP Hydrolysis Reactions of Rho Family GTP-binding Proteins [PDF]
, 2000 Baolin Zhang +3 more
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Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]
, 2002 We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
core
Full-length RNA-Seq of the RHOH gene in human B cells reveals new exons and splicing patterns
Scientific ReportsThe RhoH protein is a member of the Ras superfamily of guanosine triphosphate-binding proteins. RhoH is an atypical Rho family member that is always GTP-bound and thus always activated.
Frédéric Leprêtre +7 more
doaj +1 more source
Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation [PDF]
, 2014 Antonio Cuadrado +3 more
openalex +1 more source