Results 231 to 240 of about 57,806 (244)

Rho-GTP Binding Proteins in Yersinia Target Cell Interaction

2004
Among the more than 10 Yersinia species known three are pathogenic for humans: (i) Y. pestis is the causative agent of plaque, (ii) Y. pseudotuberculosis and (iii) Y. enterocolitica are enteropathogenic. The infection process of enteropathogenic yersiniae involves invasive as well as antiphagocytic and other immunomodulatory components.
Aepfelbacher, Martin, Trasak, Claudia, Wiedemann, Agnès, Andor, Andreas   +3 more
openaire   +4 more sources

Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1997
The endothelial cytoskeleton is important for the regulation of endothelial barrier function. Small GTP-binding Rho proteins play a central role in the organization of the microfilament system. Clostridium difficile toxin B (TcdB) inactivates Rho proteins by glucosylation at Thr-37.
Hippenstiel, Stefan, Tannert-Otto, S., Vollrath, N., Krull, M., Just, Ingo, Aktories, Klaus, Eichel-Streiber, Christoph von, Suttorp, Norbert   +7 more
openaire   +3 more sources

Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins

Trends in Cell Biology, 1995
Rho proteins, which are involved in receptor-mediated regulation of the actin cytoskeleton, are substrates for ADP-ribosylation by Clostridium botulinum C3 toxins. Recently, it was shown that Rho and other members of the Rho subfamily of low-molecular-mass GTP-binding proteins are glucosylated by C. difficile toxins A and B.
K, Aktories, I, Just
openaire   +2 more sources

Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins

Journal of Microscopy, 2008
SummaryThe Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
openaire   +2 more sources

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

Journal of Cell Science, 1995
ABSTRACT The small GTP-binding proteins, rho and rac, control signal transduction pathways that link growth factor receptors to the activation of actin polymerization. In Swiss 3T3 cells, rho proteins mediate the lysophosphatidic acid and bombesin-induced formation of focal adhesions and actin stress fibres, whilst rac proteins are ...
C D, Nobes, P, Hawkins, L, Stephens, A, Hall   +3 more
openaire   +2 more sources

Augmentation of human leukemic cell invasion by activation of a small GTP-binding protein Rho

Experimental Hematology, 2000
The functions of a small GTP-binding protein, Rho, in human leukemic cell invasion was investigated in vivo and in vitro.Human leukemic KM3 and Reh cells (derived from B-cell-type common acute lymphoid leukemias) were inoculated into severe combined immundeficiency (SCID) mice.
S, Fukushima, T, Yamada, A, Hashiguchi, Y, Nakata, J, Hata   +4 more
openaire   +2 more sources

Characterization of a Monoclonal Antibody Specific for the Ras-Related GTP-Binding Protein Rho A

Biochemical and Biophysical Research Communications, 1993
The Rho family of small GTP-binding proteins is one of the three subgroups which, together with the Ras and Rab families, constitute the Ras-related superfamily. The Rho subgroup contains at least seven highly homologous members including 4 Rho proteins (RhoA, RhoC, RhoB, and RhoG), the Rac1 and Rac2 proteins, and CDC42Hs, which are involved in various
P, Lang, F, Gesbert, J M, Thiberge, F, Troalen, H, Dutartre, P, Chavrier, J, Bertoglio   +6 more
openaire   +2 more sources

Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cells

Canadian Journal of Physiology and Pharmacology, 1996
The actin cytoskeleton is involved in numerous cellular functions such as cell motility, mitogenesis, morphology, muscle contraction, cytokinesis, and establishment of cell polarity. The members of the Rho subfamily of small GTP-binding proteins emerge as key regulators of cytokeleton organization.
D, Boivin, D, Bilodeau, R, Béliveau
openaire   +2 more sources

Small GTP-Binding Proteins of the Rho Family in the Dictyostelium Cytoskeleton

Protist, 1998
F, Rivero, A A, Noegel
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Rho GTP-Binding Proteins

2007
openaire   +1 more source