Results 101 to 110 of about 99,117 (203)
Functional specialization of the yeast Rho1 GTP exchange factors [PDF]
, 2012 Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs).
Cundell, M. +6 more
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Activation of RhoA and ROCK Are Essential for Detachment of Migrating Leukocytesh [PDF]
, 2000 Detachment of the rear of the cell from its substratum is an important aspect of locomotion. The signaling routes involved in this adhesive release are largely unknown.
Alblas, J. +3 more
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Untangling the role of RhoA in the heart: protective effect and mechanism
Cell Death and DiseaseRhoA (ras homolog family member A) is a small G-protein that transduces intracellular signaling to regulate a broad range of cellular functions such as cell growth, proliferation, migration, and survival.
Shigeki Miyamoto
doaj +1 more source
Anillin Puts RhoA in Touch with PIP2 [PDF]
Developmental Cell, 2019 In this issue of Developmental Cell, Budnar and colleagues report how the scaffolding protein anillin uses cycles of transient binding interactions to enhance the residence time and signaling output of active RhoA to control actomyosin contractility at epithelial junctions and during cell division.
openaire +2 more sources
The Journal of Cell Biology, 2001 In fibroblasts, the small GTPase RhoA is required for the formation of integrin-containing adhesions. Surprisingly, Worthylake et al. (page 147) have found that RhoA serves a different purpose in monocytes, apparently operating as a negative regulator of integrin adhesions at the rear of migrating cells.
openaire +1 more source
Cell Death and DiseaseRhoA, a small GTPase, plays a pivotal role in various diseases, including spinal cord injury (SCI). Although RhoA inhibition has been traditionally viewed as beneficial for SCI repair, recent clinical trials of RhoA inhibitors in SCI have failed to show ...
Jiale Cai +12 more
doaj +1 more source
Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]
, 2002 The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L. +4 more
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Blood Advances: The RHOA G17V mutation is highly recurrent in T follicular helper (TFH) cell lymphoma of the angioimmunoblastic type (AITL; 60%-70% of cases) and frequently associated with mutations in other T-cell receptor signaling genes, including CD28.
David Vallois +7 more
doaj +1 more source
DIFFERENTIAL RHOA ACTIVITY IN CHONDROCYTES UNDER FLOW [PDF]
, 2012 poster abstractMechanical force environment is a major factor that influences cellular homeostasis and remodeling. The prevailing wisdom in this field demon-strated that a threshold of mechanical forces or deformation was required to affect cell ...
Na, Sungsoo +2 more
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Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]
, 2002 We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
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