Results 221 to 230 of about 123,069 (394)

Single-component optogenetic tools for inducible RhoA GTPase signaling [PDF]

, 2021
Erin E. Berlew, Ivan A. Kuznetsov, Keisuke Yamada, Lukasz J. Bugaj, Joel D. Boerckel, Brian Y. Chow   +5 more
openalex   +1 more source

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics

Cell Proliferation, EarlyView.
Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin, Pengyu Wei, Mengyang Zhang, Kang Li, Lina Li, Zhipeng Li, Changcheng Luo, Wenbo Kuang, Kai Cui, Zhong Chen   +9 more
wiley   +1 more source

Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism

, 2016
Feng‐Shuang Yi, Ruirui Kong, Jinqi Ren, Li Zhu, Jizhong Lou, Jane Y. Wu, Wei Feng   +6 more
openalex   +1 more source

RHOA wt Allele [PDF]

, 2020
openaire   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Transforming Protein RhoA [PDF]

, 2020
openaire   +1 more source

Decoding the Role of Caveolin‐1 in Morphological Diversity and Self‐Renewal of Breast Cancer Cells

Cell Proliferation, EarlyView.
The silence of caveolin‐1 (Cav‐1) reproduced the morphological evolutionary behaviour of cancer cells, which is similar to the epithelial‐mesenchymal transition process. And Cav‐1 dependent morphological changes could affect cancer cell self‐renewal capacity through maintaining the morphological stability.
Shun Li, Hongyun Duan, Lu Yang, Lingyi Jiang, Haocheng Bian, Yuqin Jiang, Yixi Zhang, Wei Yan, Qin Yang, Tingting Li, Xiang Qin, Zong‐Yuan Liu, Ningwei Sun, Kai‐fu Yang, Yiyao Liu   +14 more
wiley   +1 more source

Leveraging online reviews to decode quality‐induced customer dissatisfaction: From perception to product discouragement

Decision Sciences, EarlyView.
Abstract E‐commerce practitioners and researchers recognize that quality concerns are the primary drivers of customer dissatisfaction with products or services. While dissatisfaction can arise from various factors, little is known about quality and its components, specifically from the perspective of dissatisfied customers. Grounded in the foundational
Rahul Kumar, Nolan M. Talaei, Ajay Kumar, Kristof Coussement, Asil Oztekin   +4 more
wiley   +1 more source

Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse [PDF]

, 2018
Max Nobis, David Herrmann, Sean Warren, Douglas Strathdee, Thomas R. Cox, Kurt I. Anderson, Paul Timpson   +6 more
openalex   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source