Results 221 to 230 of about 104,378 (298)

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, Volume 20, Issue 21, November 6, 2025.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

RHOA-dependent regulation of mitochondrial remodeling and cell motility in hypoxia-exposed gastric epithelial cells. [PDF]

J Cell Sci
Pal A, Bawali P, Brahma A, Rana SR, Mohapatra R, Chakraborty D, Poirah I, Samal S, Banerjee S, Smoot DT, Ashktorab H, Bhattacharyya A.   +11 more
europepmc   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, Volume 19, Issue 11, Page 3360-3375, November 2025.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Bone Microstructural Deterioration and miR-155/<i>RHOA</i>-Mediated Osteoclastogenesis in Type 2 Diabetes Mellitus. [PDF]

Int J Mol Sci
Alaleeli MM, Kaimala S, Adeghate E, Mohsin S.   +3 more
europepmc   +1 more source

Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects [PDF]

, 2015
Gisele Espinha, Juliana Harumi Osaki, Érico T. Costa, Fábio Luís Forti   +3 more
openalex   +1 more source

Thermal Annealing Enhances Piezoelectricity and Regenerative Potential of PVDF‐TrFE Nanofiber Scaffolds

Advanced Materials Technologies, Volume 10, Issue 21, November 6, 2025.
Thermal annealing improves the structure, stiffness, and piezoelectric properties of poly(vinylidene flouride‐trifluoroethylene) (PVDF‐TrFE) nanofiber scaffolds. These annealed scaffolds promote Schwann cell proliferation and matrix remodeling in vitro and demonstrate in vivo biocompatibility.
Maksym Krutko, Holly M. Poling, Maulee Sheth, Supasek Kongsomros, Andrew E. Bryan, Manju Sharma, Akaljot Singh, Hasan A. Reza, Kathryn A. Wikenheiser‐Brokamp, Takanori Takebe, Michael A. Helmrath, Greg M. Harris, Leyla Esfandiari   +12 more
wiley   +1 more source

CRB3 and NF2 orchestrate cytoskeletal dynamics to control epithelial barrier assembly. [PDF]

JCI Insight
Fan S, Varadarajan S, Garcia-Hernandez V, Flemming S, Raya-Sandino A, Margolis B, Parkos CA, Nusrat A.   +7 more
europepmc   +1 more source

TMEM16A Maintains Acrosomal Integrity Through ERK1/2, RhoA, and Actin Cytoskeleton During Capacitation [PDF]

Ana L. Roa‐Espitia, Tania Reyes‐Miguel, Monica L. Salgado‐Lucio, Joaquín Cordero‐Martínez, Dennis Tafoya-Domínguez, Enrique O. Hernández‐González   +5 more
openalex   +1 more source

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu, Xuyu Zhao, Zixin Chen, Jingying Huang, Tengteng Dai, Jianxin Zhou, Luyao Xiao, Luonan Chen, Robert Chunhua Zhao, Jiao Wang   +9 more
wiley   +1 more source

Pleiotrophin modulates cell proliferation, prostate smooth muscle contraction and fibrosis in hyperplastic prostate. [PDF]

J Transl Med
Liu J, Fan J, Liu H, Chen M, Fu X, Zhao Y, Cheng M, Guo Y, Li Y, Liu J, Wu Z, Li Y, DiSanto ME, Zhang X, Chen P.   +14 more
europepmc   +1 more source