Results 231 to 240 of about 104,378 (298)

Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple‐Negative Breast Cancer

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study identified that STK33 may serve as a target of Bufalin, which induces the degradation of STK33 and inhibits the growth of TNBC. Furthermore, STK33 is highly expressed in TNBC and enhances TNBC cell proliferation by phosphorylating and stabilizing CCAR1.
Shilong Jiang, Junyan Liu, Hui Li, Chan Zou, Xiaoya Wan, Rong Gong, Ting Jiang, Changxin Zhong, Zonglin Chen, Zewu Zhu, Dongsheng Cao, Yan Cheng   +11 more
wiley   +1 more source

A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia. [PDF]

Sci Adv
Elliott SD, Ready PJ, Wrinn CM, Ma Q, Edward M, Niescier RF, Escobar I, Sun J, Ganga AK, McAtee CK, Atiş İS, Koleske AJ, Bordey A, Breslow DK.   +13 more
europepmc   +1 more source

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen, Zhicong Liu, Qiang Shu, Bin Zhou   +3 more
wiley   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets. [PDF]

MedComm (2020)
Lin Z, Ni C, Jiang H, Yang H, Deng L, Liu P, Li X, Yu Y, Li W, Wang R, Liao B, Kang J, Liu J, Wu X, Ren J, Zhao Y.   +15 more
europepmc   +1 more source

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu   +12 more
wiley   +1 more source

Non-muscle myosin II-dependent cumulus cell migration at ovulation is required for sperm to reach the egg in mice. [PDF]

Commun Biol
Carvalho KF, Clarke HJ.
europepmc   +1 more source

Magnetized Cell‐Scaffold Constructs for Bone Tissue Engineering: Advances in Fabrication and Magnetic Stimulation

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This review highlights the synthesis and applications of magnetized cells (MCs) and magnetized scaffolds (MSs) in advancing bone tissue engineering strategies. It further demonstrates how magnetic particles (MPs) improve scaffold properties and how external magnetic fields enhance mesenchymal stem cell adhesion, proliferation, and osteogenic ...
Elio Cinar SanSegundo, Mohammad J. Mirzaali, Lidy E. Fratila‐Apachitei, Amir A. Zadpoor   +3 more
wiley   +1 more source

C1-linker region of PARG1 RhoGAP promotes the catalytic recognition fold of RhoA substrate. [PDF]

PLoS One
Kouchi Z, Kojima M.
europepmc   +1 more source

Shexiang Tongxin dropping pills ameliorate myocardial ischemia-reperfusion injury progression via the S1PR2/RhoA/ROCK pathway

Ying Sun, Boyang Jiao, Yizhou Liu, Ran Wang, Qiong Deng, David N. Criddle, Yulin Ouyang, Wei Wang, Xuegong Xu, Chun Li   +9 more
openalex   +1 more source

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan, Yuyu Li, Shuo Chen, Li Zhu, Chenchen Zhou, Jianwei Chen, Shujuan Zou, Xianglong Han   +7 more
wiley   +1 more source