Results 51 to 60 of about 3,694 (201)

Some Molecular Properties of Rhodanese

Journal of Biological Chemistry, 1970
Abstract Fluorescence studies of crystalline bovine liver rhodanese indicate that the reactive sulfhydryl group is in a region which can participate in hydrophobic (apolar) interactions. Fluorescence polarization studies confirm that rhodanese exists in a mobile monomer-dimer equilibrium.
P, Horowitz, J, Westley
openaire   +2 more sources

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source

Genetic diversity of ‘Candidatus Phytoplasma mali’ strains in Poland

Phytopathologia Mediterranea, 2015
During 2010-2013, samples from 267 apple trees growing in six regions of Poland were tested for phytoplasma presence. ‘Candidatus Phytoplasma mali’ was detected in 17 samples from phloem tissue of apple shoots showing typical apple proliferation symptoms.
Mirosława CIEŚLIŃSKA, Ewa HENNIG, Dorota KRUCZYŃSKA, Assunta BERTACCINI   +3 more
doaj   +1 more source

Impact of intestinal microbiota on metabolic toxicity and potential detoxification of amygdalin

Frontiers in Microbiology, 2022
Amygdalin (Amy) is metabolized into cyanide in vivo, which may lead to fatal poisoning after oral administration. The defense mechanisms against toxic cyanide have not yet been adequately studied.
Qiuyu Wen, Qiuyu Wen, Shen Yu, Shen Yu, Shanshan Wang, Shanshan Wang, Yan Qin, Yan Qin, Quan Xia, Quan Xia, Sheng Wang, Guanjun Chen, Chenlin Shen, Shuai Song, Shuai Song   +14 more
doaj   +1 more source

An Expanded Mechanism for Rhodanese Catalysis

Journal of Biological Chemistry, 1974
Abstract The kinetic behavior of rhodanese (thiosulfate:cyanide sulfurtransferase, EC 2.8.1.1) was investigated at pH values from 5.0 to 10.8. The binding of thiosulfate was shown to be dependent upon a pK' of 9.9, with the protonated enzyme binding the substrate much more strongly than the deprotonated form. An enzymic nucleophile displaces sulfite to
P, Schlesinger, J, Westley
openaire   +2 more sources

AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ‐Secretase Assembly

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
AHA1 regulates Aβ production through dual mechanisms. AHA1 promotes APP abundance through mechanisms that are at least partially independent of Hsp90 interaction, while cooperating with Hsp90 to regulate APH1/NCT pre‐complex formation, γ‐secretase assembly, and γ‐secretase activity. These coordinated mechanisms contribute to increased Aβ generation and
Arshad Ali Noorani, Sadequl Islam, Emma Filip, Kevin Catalfano, Shravan Paswan, Vaishnavi Nagarajan, Heather M. Wilkins, Brian S. J. Blagg, Kun Zou, Michael S. Wolfe   +9 more
wiley   +1 more source

Specific interactions of lipoate at the active site of rhodanese

, 2000
Dihydrolipoate is an acceptor of the rhodanese-bound sulfane sulfur atom, as shown by analysis of the elementary steps of the reaction catalyzed by rhodanese.
F. GLIUBICH, M. CIANCI, ZANOTTI, GIUSEPPE   +2 more
core   +1 more source

Characterization of rhodanese synthesized by the wild and EMS-mutated Klebsiella oxytoca JCM1665

Journal of Agriculture and Food Research
Cyanide poisoning remains a significant concern for both civilian and military personnel worldwide. Rhodanese, a cyanide detoxify enzyme produced by the wild (KOJCM1665) and two selected mutant strains (KOJCM1665c and KOJCM1665d) of Klebsiella oxytoca ...
Babamotemi Oluwasola Itakorode, Oladayo Emmanuel Apalowo, Isaac Duah Boateng, Raphael Emuebie Okonji   +3 more
doaj   +1 more source

The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley   +1 more source

Studies on the Active Site of Rhodanese

Journal of Biological Chemistry, 1968
Abstract The complete loss of enzymic activity on reaction with alkylating agents, aromatic nitro compounds, or aliphatic mercaptans indicates the importance of sulfhydryl groups for catalysis. Analyses during the course of inactivation with any of these reagents revealed the loss of one of the two —SH groups in the rhodanese monomer when inactivation ...
S F, Wang, M, Volini
openaire   +2 more sources