Results 51 to 60 of about 178 (132)

Biodegradation of Cyanide-Based Compounds by Rhodanese Produced from Kocuria rhizophila Under Submerged Fermentation and Its Role in Environmental Detoxification

Molecules
Widespread release of cyanide from industrial activities represents a significant environmental challenge due to its acute toxicity and adverse effects on biological systems.
Nada Z. Mahdi, Suhair Sh. Al-Siraj, Nehad A. Taher, Muneefah Abdullah Alenezi, Khyreyah J. Alfifi, Fauzeya Mateq Albalwe, Hanan Khalaf Anazi, Siham M. AL-Balawi, Mahmoud Galal, Maha F. Lotfy, Eman M. Sharaf   +10 more
doaj   +1 more source

Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes

Scientific Reports, 2022
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, was initially discovered as a cyanide detoxification enzyme. However, it was recently also found to be a genetic predictor of resistance to obesity-related type 2 diabetes ...
Zayana M. Al-Dahmani, Xiaogang Li, Lucas M. Wiggenhauser, Hannes Ott, Paul D. Kruithof, Sergey Lunev, Fernando A. Batista, Yang Luo, Amalia M. Dolga, Nicholas M. Morton, Matthew R. Groves, Jens Kroll, Harry van Goor   +12 more
doaj   +1 more source

Bioleaching Microbial Community Metabolism and Composition Driven by Copper Sulphide Mineral Type

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Bioleaching is a microbially mediated green technology for the recovery of metals from ore. Here, microbial consortia from a copper bioleaching column in Cyprus were cultivated on chalcopyrite (CuFeS2) and then sub‐cultured on chalcocite (Cu2S) and chalcopyrite to investigate how mineral type and surface chemistry influence microbial community ...
Katherine R. Lane, Sarah E. Jones, Thomas H. Osborne, David Geller‐McGrath, Bennet C. Nwaobi, LinXing Chen, Brian C. Thomas, Karen A. Hudson‐Edwards, Jillian F. Banfield, Joanne M. Santini   +9 more
wiley   +1 more source

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery

British Journal of Pharmacology, Volume 182, Issue 22, Page 5453-5468, November 2025.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +1 more source

In Hyphomicrobium denitrificans Two Related Sulfane‐Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses

Molecular Microbiology, Volume 124, Issue 3, Page 204-220, September 2025.
In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li, Nora E. Schmitte, Kaya Törkel, Christiane Dahl   +3 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, Volume 599, Issue 16, Page 2362-2376, August 2025.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Effects of the Gut microbiota on Amygdalin and its use as an anti-cancer therapy: Substantial review on the key components involved in altering dose efficacy and toxicity

Biochemistry and Biophysics Reports, 2018
Conventional and Alternative Medicine (CAM) is popularly used due to side-effects and failure of approved methods, for diseases like Epilepsy and Cancer.
Vani Jaswal, Jeyanthi Palanivelu, Ramalingam C, Dr   +2 more
doaj   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Enzymes as Biomarkers of Environmental Stress in African Catfish (Clarias gariepinus) in Osun State, Nigeria

Journal of Health and Pollution, 2017
Background. Many natural aquatic bodies have been contaminated with heavy metals released from domestic, industrial and other anthropogenic activities.
Omolara Titilayo Aladesanmi, Femi Kayode Agboola, Rapheal Emuebe Okonji   +2 more
doaj   +1 more source