Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry [PDF]
, 2020 We describe a new technique, high fidelity Imaging Retinal Densitometry (IRD), which probes the functional integrity of the outer retinal complex. We demonstrate the ability of the technique to map visual pigment optical density and synthesis rates in ...
Atkinson, D. +11 more
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Molecular logic behind the three-way stochastic choices that expand butterfly colour vision. [PDF]
, 2016 Butterflies rely extensively on colour vision to adapt to the natural world. Most species express a broad range of colour-sensitive Rhodopsin proteins in three types of ommatidia (unit eyes), which are distributed stochastically across the retina.
Arikawa, Kentaro +5 more
core +1 more source
Incorporation of membrane proteins into large single bilayer vesicles. Application to rhodopsin. [PDF]
, 1979 A general procedure to incorporate membrane proteins in a native state into large single bilayer vesicles is described. The results obtained with rhodopsin from vertebrate and invertebrate retinas are presented.
Darszon, A +3 more
core
Development of an antibody fragment that stabilizes GPCR/G-protein complexes. [PDF]
, 2018 Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological macromolecular complexes.
Dawson, Roger JP +9 more
core +2 more sources
Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation. [PDF]
, 2007 For over a decade, phosducin's interaction with the betagamma subunits of the G protein, transducin, has been thought to contribute to light adaptation by dynamically controlling the amount of transducin heterotrimer available for activation by ...
Arshavsky, Vadim Y +6 more
core
Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation [PDF]
, 2007 Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis ...
Kim, Soo-Kyung +3 more
core +1 more source
The F220C and F45L rhodopsin mutations identified in retinitis pigmentosa patients do not cause pathology in mice. [PDF]
, 2020 Retinitis pigmentosa is a retinal degenerative disease that leads to blindness through photoreceptor loss. Rhodopsin is the most frequently mutated protein in this disease.
Arshavsky, Vadim Y +5 more
core +1 more source
Fluctuations of Complex Networks: Electrical Properties of Single Protein Nanodevices
, 2004 We present for the first time a complex network approach to the study of the electrical properties of single protein devices. In particular, we consider an electronic nanobiosensor based on a G-protein coupled receptor.
Akimov, V. +4 more
core +1 more source
Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]
, 2007 A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G., Woodwark, Mathew
core +2 more sources
Mutations in splicing factor genes are a major cause of autosomal dominant retinitis pigmentosa in Belgian families [PDF]
, 2017 Purpose : Autosomal dominant retinitis pigmentosa (adRP) is characterized by an extensive genetic heterogeneity, implicating 27 genes, which account for 50 to 70% of cases.
Casteels, Ingele +14 more
core +3 more sources