The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas [PDF]
Journal of Venomous Animals and Toxins Including Tropical Diseases, 2013 Backgound The venom of the Cuban scorpion Rhopalurus junceus is poorly study from the point of view of their components at molecular level and the functions associated.
Fredy I V Coronas +2 more
exaly +8 more sources
Rhopalurus junceus scorpion venom induces G2/M cell cycle arrest and apoptotic cell death in human non-small lung cancer cell lines [PDF]
Journal of Venomous Animals and Toxins Including Tropical DiseasesBackground: Non-small cell lung cancers (NSCLC) represent the primary cause of cancer-related deaths worldwide. Rhopalurus junceus venom has been shown to exert cytotoxic effects against a panel of epithelial cancer cells in vitro and suggested that ...
Alexis Díaz-García +2 more
exaly +6 more sources
Therapeutic Anticancer Uses of the Active Principles of “Rhopalurus junceus” Venom [PDF]
Biomedicines, 2020 The Rhopalurus junceus is a scorpion belonging to the Buthidae family that finds its habitat in Cuba. This scorpion is known by the common name of “Blue Scorpion”.
Mario Dioguardi +10 more
doaj +6 more sources
Rhopalurus junceus scorpion venom induces antitumor effect in vitro and in vivo against a murine mammary adenocarcinoma model [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): In Cuba the endemic scorpion species Rhopalurus junceus has been used in traditional medicine for cancer treatment and related diseases. However there is no scientific evidence about its therapeutic potential for cancer treatment.
Alexis Díaz-García +7 more
doaj +4 more sources
Variation of cytochrome oxidase-I gene and venom proteins of Rhopalurus junceus populations in the Moanicum sector: Pharmacological implications [PDF]
Journal of Pharmacy and Pharmacognosy Research, 2021 Context: In Cuba, the venom of the endemic scorpion Rhopalurus junceus has been used in traditional medicine for cancer treatment. The genetic variability in populations from distinct origin and differences in the composition of venom –a little explored ...
Rodolfo Rodríguez-Ravelo +5 more
exaly +3 more sources
Pharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice after Intravenous and Oral Administration [PDF]
Iranian Biomedical Journal, 2019 Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice.131I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12.5 mg/kg.
Alexis Díaz-García +2 more
exaly +5 more sources
Synergistic effect of Rhopalurus junceus scorpion venom combined with conventional cytostatics in cervical cancer cell line HeLa [PDF]
Journal of Pharmacy and Pharmacognosy Research, 2019 Context: Venom from endemic scorpion of Cuba, Rhopalurus junceus, decreases the viability of epithelial cancer cells and has negligible cytotoxic effect on normal cells.
Arianna Yglesias-Rivera +2 more
exaly +3 more sources
Journal of the Dow University of Health Sciences, 2021 Over the years, cancer treatment has focused on its eradication once it has been detected, however, it's common to find that a large number of neoplasms redevelop in patients, which reduces their quality and life expectancy when going through surgical ...
Perla Yazmin Pichardo Jaimes +2 more
doaj +3 more sources
Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines. [PDF]
Evid Based Complement Alternat Med, 2019 Cervical cancer (CC) is classified as the fourth most common type of cancer in women worldwide and remains a serious public health problem in many underdeveloped countries. Human papillomavirus (HPV), mainly types 16 and 18, has been established as a precursory etiologic agent for this type of cancer.
Bernardes-Oliveira E +8 more
europepmc +2 more sources
Synergism of the combination of Rhopalurus junceus scorpion venom with conventional cytostatics in the ct26 tumor cell line. [PDF]
Asian Journal of Biomedical and Pharmaceutical Sciences, 2020 Introduction: The endemic scorpion venom of Cuba, Rhopalurus junceus (R. junceus), decreases the viability of tumor cells of epithelial origin and has no cytotoxic effect on normal cells. However, its antineoplastic effect on murine colon tumor cells and the type of pharmacological interaction of its combination with conventional chemotherapeutic
Arianna Yglesias-Rivera +3 more
exaly +2 more sources