Analysis of Hepatitis C Viral Dynamics Using Latin Hypercube Sampling [PDF]
, 2011 We consider a mathematical model comprising of four coupled ordinary differential equations (ODEs) for studying the hepatitis C (HCV) viral dynamics. The model embodies the efficacies of a combination therapy of interferon and ribavirin. A condition for the stability of the uninfected and the infected steady states is presented.
Dahari +17 more
arxiv +3 more sources
Efficacy and Safety of Adding Ribavirin to Sofosbuvir-Based Direct-Acting Antivirals (DAAs) in Re-Treating Non-Genotype 1 Hepatitis C—A Systematic Review and Meta-Analysis [PDF]
DiseasesBackground: There is still debate whether ribavirin should be added to direct-acting antivirals (DAAs) for the management of treatment-experienced individuals with non-genotype-1 hepatitis C.
Shahd Hamran +10 more
doaj +2 more sources
Baseline MELD score predicts hepatic decompensation during antiviral therapy in patients with chronic hepatitis C and advanced cirrhosis [PDF]
, 2013 Background and Aims: In patients with advanced liver cirrhosis due to chronic hepatitis C virus (HCV) infection antiviral therapy with peginterferon and ribavirin is feasible in selected cases only due to potentially life-threatening side effects ...
Dultz, Georg +11 more
core +21 more sources
Frontiers in Public Health, 2021 Background: Intravenous (IV) ribavirin is not approved in US and European Union, but it is authorized in China. Significant teratogenic and embryocidal effects of ribavirin have been found in almost all animal studies, it is critical to investigate the ...
Hailong Li +5 more
doaj +1 more source
Ribavirin enhances the action of interferon-α against hepatitis C virus by promoting the p53 activity through the ERK1/2 pathway. [PDF]
PLoS ONE, 2012 Background/aimsRibavirin significantly enhances the antiviral response of interferon-α (IFN-α) against Hepatitis C virus (HCV), but the underlying mechanisms remain poorly understood. Recently, p53 has been identified as an important factor involving the
Wei-Liang Liu +8 more
doaj +1 more source
Time to reconsider the role of ribavirin in Lassa fever.
PLoS Neglected Tropical Diseases, 2021 Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is based on one clinical study conducted in the early 1980s. However, reanalysis of previous unpublished data reveals that ribavirin may actually be harmful in some ...
Alex Paddy Salam +5 more
doaj +1 more source
Ribavirin-induced anemia in hepatitis C virus patients undergoing combination therapy. [PDF]
PLoS Computational Biology, 2011 The current standard of care for hepatitis C virus (HCV) infection - combination therapy with pegylated interferon and ribavirin - elicits sustained responses in only ∼50% of the patients treated.
Sheeja M Krishnan, Narendra M Dixit
doaj +1 more source
Inhibition of tick-borne encephalitis virus in cell cultures by ribavirin
Frontiers in Microbiology, 2023 Tick-borne encephalitis virus (TBEV) belonging to arboviruses is a major member of zoonotic pathogens. TBEV infection causes severe human encephalitis without specific antiviral drugs.
Wan-Da Tang +5 more
doaj +1 more source
Optimal dosage of ribavirin† [PDF]
Hepatology, 2010 n ...
Mangia, Alessandra, Andriulli, Angelo
openaire +4 more sources