Results 31 to 40 of about 61,737 (200)

Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase

Analytical Cellular Pathology, 2015
Microglia play a key role in defending central nervous system from various internal and external threats. However, their excessive and/or chronic activation is associated with deleterious effects in a variety of neurodegenerative diseases. Previously, we
Iva Bozic, Danijela Savic, Marija Jovanovic, Ivana Bjelobaba, Danijela Laketa, Nadezda Nedeljkovic, Mirjana Stojiljkovic, Sanja Pekovic, Irena Lavrnja   +8 more
doaj   +1 more source

Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease.

Gastroenterology, 2015
BACKGROUND & AIMS There are no effective and safe treatments for chronic hepatitis C virus (HCV) infection of patients who have advanced liver disease. METHODS In this phase 2, open-label study, we assessed treatment with the NS5A inhibitor ledipasvir,
M. Charlton, G. Everson, S. Flamm, Princy N. Kumar, C. Landis, Robert S. Brown, M. Fried, N. Terrault, J. O’Leary, H. Vargas, A. Kuo, E. Schiff, M. Sulkowski, R. Gilroy, K. Watt, K. Brown, P. Kwo, S. Pungpapong, K. Korenblat, A. Muir, L. Teperman, R. Fontana, J. Denning, S. Arterburn, H. Dvory‐Sobol, T. Brandt-Sarif, P. Pang, J. Mchutchison, K. Reddy, N. Afdhal, M. Fried, K. Kowdley, N. Terrault, S. Flamm, J. Lake, G. Everson, M. Sulkowski, M. Curry, R. Reddy, H. Vargas, A. Muir, A. Zaman, R. Fontana, J. O’Leary, O. Shaikh, K. Korenblat, R. Stravitz, K. Watt, N. Menon, J. Bredfeldt, Carlos Romero‐Marrero   +50 more
semanticscholar   +1 more source

Influence of Ribavirin Serum Levels on Outcome of Antiviral Treatment and Anemia in Hepatitis C Virus Infection.

PLoS ONE, 2016
BackgroundRibavirin blood levels vary considerably between patients with standard weight-based dosing. Their impact on sustained virological response (SVR) with pegylated interferon and ribavirin is controversial, but has mostly been studied before the ...
Thomas Kuntzen, Sereina Kuhn, Daniela Kuntzen, Burkhardt Seifert, Beat Müllhaupt, Andreas Geier   +5 more
doaj   +1 more source

Influence of chemotherapy on development and production of virus free in vitro strawberry plants

Horticultural Science, 2019
The objective of the study was to determine effects of ribavirin on development and health status of in vitro grown strawberry cultivars 'Honeoye' and 'Elkat' infected with viruses Strawberry mild yellow-edge virus (SMYEV), Tomato ringspot virus (ToRSV ...
Jiří Sedlák, František Paprštein, Jana Suchá   +2 more
doaj   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Crystallization Selectivity of Ribavirin Solution and Amorphous Phase

Molecules, 2023
Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and
Fuying Li, Shiying Chen, Haoxin Hu, Chengfeng Liang, Shiyu Sun, Can Jin, Fenghua Chen   +6 more
doaj   +1 more source

Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post‐liver transplantation recurrence

Hepatology, 2016
Chronic hepatitis C virus (HCV) infection with advanced cirrhosis or post‐liver transplantation recurrence represents a high unmet medical need with no approved therapies effective across all HCV genotypes. The open‐label ALLY‐1 study assessed the safety
F. Poordad, E. Schiff, J. Vierling, C. Landis, R. Fontana, Rong Yang, F. Mcphee, E. Hughes, S. Noviello, E. Swenson   +9 more
semanticscholar   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Ribavirin and its analogs: Сan you teach an old dog new tricks?

Тонкие химические технологии, 2019
The review article focuses on the current state of synthetic and biological studies of ribavirin analogs. Ribavirin is a broad-spectrum nucleoside antiviral drug with a 50-year long history of research and application, but its mechanism of action still ...
M. V. Chudinov
doaj   +1 more source