Results 61 to 70 of about 76,496 (274)

Synthesis, Characterization, and Bioactivity of Quinoxaline Thiazolotriazoles

Journal of Heterocyclic Chemistry, EarlyView.
Quinoxaline thiazolotriazole target molecules with antibacterial, antitubercular and antidiabetic activity. ABSTRACT A total of 10 quinoxaline thiazolo[2,3‐c][1,2,4]triazole hybrid molecules were synthesized in a four‐step synthetic protocol. Six of these compounds are reported here for the first time.
Silungile Mhlongo, Sibusiso Senzani, Shahidul Islam, Kolawole Olofinsan, Moganavelli Singh, Nirasha Nundkumar, Sithabile Mokoena, Rajshekhar Karpoormath, Neil A. Koorbanally   +8 more
wiley   +1 more source

Ribavirin and its analogs: Сan you teach an old dog new tricks?

Тонкие химические технологии, 2019
The review article focuses on the current state of synthetic and biological studies of ribavirin analogs. Ribavirin is a broad-spectrum nucleoside antiviral drug with a 50-year long history of research and application, but its mechanism of action still ...
M. V. Chudinov
doaj   +1 more source

A new paradigm evaluating cost per cure of HCV infection in the UK [PDF]

, 2016
Background: New interferon (IFN)-free treatments for hepatitis C are more effective, safer but more expensive than current IFN-based therapies. Comparative data of these, versus current first generation protease inhibitors (PI) with regard to costs and ...
Aline Gauthier, Elizabeth Holtham, Graham S. Cooke, Jeremie Schwarzbard, null null, Petar Atanasov, Stephen T. Barclay, William L. Irving   +7 more
core   +2 more sources

SOFOSBUVIR AND RIBAVIRIN

The Professional Medical Journal, 2018
Objectives: This study was conducted to evaluate the 16-weeks versus 24-weeks efficacy of sofosbuvir and ribavirin in HCV genotype-3a infection. Study Design: Open labeled, single center, longitudinal study. Setting: Khyber Medical College and Khyber Teaching Hospital, Peshawar.
Abid Shah, Nizamud din, Jamalud Din, Waheed Iqbal   +3 more
openaire   +2 more sources

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source

Peginterferon alfa-2a plus ribavirin for treating chronic hepatitis C virus infection: Analysis of Mexican patients included in a multicenter international clinical trial

Annals of Hepatology, 2003
Treatment with polyethylene glycol-modified interferon alfa-2a (peginterferon) alone produces significantly higher sustained antiviral responses than treatment with interferon alfa-2a alone in patients with chronic hepatitis C virus (HCV) infection.
Francisco Bosques-Padilla, MD, Rafael Trejo-Estrada, MD, Octaivio Campollo-Rivas, MD, Carlos Cortez-HernÁndez, MD, Margarita Dehesa-Violante, MD, Héctor Maldonado-Garza, MD, Raúl Pérez-Gómez, MD, Armando Cabrera-Valdespino, MD   +7 more
doaj   +1 more source

Influence of Ribavirin on Mumps Virus Population Diversity

Viruses, 2021
Frequent mumps outbreaks in vaccinated populations and the occurrence of neurological complications (e.g., aseptic meningitis or encephalitis) in patients with mumps indicate the need for the development of more efficient vaccines as well as specific ...
Mirna Jurković, Anamarija Slović, Dubravko Forčić, Jelena Ivančić-Jelečki, Tanja Košutić-Gulija, Maja Jagušić   +5 more
doaj   +1 more source

Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study examines the impact of hepatitis C virus (HCV) eradication through sofosbuvir/velpatasvir (SOF/VEL) treatment on glycated hemoglobin (HbA1c) levels in patients with chronic hepatitis C and type 2 diabetes mellitus (T2DM). Utilizing data from the Taiwan HCV Registry, a retrospective analysis was conducted on 2180 patients who met the
Szu‐Jen Wang, Te‐Sheng Chang, Ching‐Chu Lo, Chao‐Hung Hung, Chien‐Wei Huang, Lee‐Won Chong, Pin‐Nan Cheng, Ming‐Jong Bair, Ming‐Lun Yeh, Cheng‐Yuan Peng, Chien‐Yu Cheng, Jee‐Fu Huang, Chih‐Lang Lin, Chi‐Chieh Yang, Hsing‐Tao Kuo, Tsai‐Yuan Hsieh, Tzong‐Hsi Lee, Pei‐Lun Lee, Wen‐Chih Wu, Chih‐Lin Lin, Wei‐Wen Su, Sheng‐Shun Yang, Chia‐Chi Wang, Jui‐Ting Hu, Lein‐Ray Mo, Chun‐Ting Chen, Yi‐Hsiang Huang, Chun‐Chao Chang, Chia‐Sheng Huang, Guei‐Ying Chen, Chien‐Neng Kao, Chi‐Ming Tai, Chun‐Jen Liu, Mei‐Hsuan Lee, Pei‐Chien Tsai, Shu‐Chi Wang, Chia‐Yen Dai, Jia‐Horng Kao, Han‐Chieh Lin, Wang‐Long Chuang, Kuo‐Chih Tseng, Chi‐Yi Chen, Chung‐Feng Huang, Ming‐Lung Yu   +43 more
wiley   +1 more source

Retreatment of hepatitis C non-responsive to Interferon. A placebo controlled randomized trial of Ribavirin monotherapy versus combination therapy with Ribavirin and Interferon in 121 patients in the Benelux [ISRCTN53821378]

BMC Gastroenterology, 2003
Background Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials.
Delwaide Jean, Michielsen Peter, Nevens Frederik, Adler Michael, Brouwer Johannes T, Veldt Bart J, Hansen Bettina E, Schalm Solko W   +7 more
doaj   +1 more source

Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection. [PDF]

PLoS ONE, 2016
In this pilot study (RibaC), 58 hepatitis C virus (HCV) genotype 1 infected treatment-naïve patients were randomized to (i) 2 weeks ribavirin double dosing concomitant with pegylated interferon-α (pegIFN-α), (ii) 4 weeks ribavirin mono-therapy prior to ...
Jesper Waldenström, Johan Westin, Kristina Nyström, Peer Christensen, Olav Dalgard, Martti Färkkilä, Karin Lindahl, Staffan Nilsson, Gunnar Norkrans, Henrik Krarup, Hans Norrgren, Mads Rauning Buhl, Stephan Stenmark, Martin Lagging   +13 more
doaj   +1 more source