Discovery of a Novel Non‐Nucleoside Inhibitor of RNA‐Dependent RNA Polymerase Against Dengue Virus
MedComm, Volume 6, Issue 12, December 2025.PN‐1, a novel non‐nucleoside inhibitor of the dengue virus RNA‐dependent RNA polymerase (RdRp), was identified from Panax notoginseng. This compound selectively targets the DENV‐2 NS5 RdRp, inducing conformational changes that inhibit enzymatic activity, thereby suppressing DENV replication both in vitro and in vivo.
Xue‐Mei He +11 more
wiley +1 more source
Ribavirin as a beneficial treatment option for hepatitis C virusassociated glomerular disease
Saudi Journal of Kidney Diseases and Transplantation, 2020 The management of hepatitis C virus (HCV)-induced glomerular disease remains unsatisfactory despite novel advances in antiviral and immunosuppressive therapy.
Fabrizio Fabrizi +7 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 72, Issue 12, December 2025.ABSTRACT Background Hemorrhagic cystitis (HC) is a frequent and potentially severe complication following hematopoietic stem cell transplantation (HSCT) in children. It significantly affects the quality of life and prolongs hospitalization. Despite its frequency, no standardized management guidelines exist.
Pauline Mazilier +8 more
wiley +1 more source
Viruses, 2012 It has been reported that inosine triphosphatase (ITPA) gene variants protect against ribavirin-induced anemia in patients treated for chronic hepatitis C.
Osamu Yokosuka +8 more
doaj +1 more source
Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis
International Journal of Infectious Diseases, 2019 Objectives: Lassa fever (LF) causes annual outbreaks in endemic regions with high mortality of symptomatic patients. Ribavirin is recommended as standard treatment for LF in national and international guidelines but the evidence base for this ...
Kirsten Alexandra Eberhardt +5 more
doaj +1 more source
Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus [PDF]
, 2018 Kristina Nystrôm +11 more
openalex +1 more source
Modeling Ribavirin‐Induced Anemia in Patients with Chronic Hepatitis C Virus
CPT: Pharmacometrics & Systems Pharmacology, 2016 Ribavirin remains an important component of hepatitis C treatment in certain clinical scenarios, but it causes hemolytic anemia. A quantitative understanding of the ribavirin exposure‐anemia relationship is important in dose individualization ...
LS Wu +4 more
doaj +1 more source
Short‐ and long‐term effects of therapy with interferon‐α and pegylated interferon‐α/ribavirin on platelet plug formation and von Willebrand factor release in patients with chronic hepatitis C [PDF]
, 2004 Monika Homoncik +7 more
openalex +1 more source
Interstitial pneumonitis associated with pegylated interferon-alpha 2a and ribavirin for chronic hepatitis C infection: a case report [PDF]
, 2009 Özlen Atuğ +5 more
openalex +1 more source
A randomized trial of high‐dose interferon alpha‐2b, with or without ribavirin, in chronic hepatitis C patients who have not responded to standard dose interferon [PDF]
, 2002 A. H. Malik +8 more
openalex +1 more source