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Riboflavin analogs and inhibitors of riboflavin biosynthesis

Applied Microbiology and Biotechnology, 2006
Flavins are active components of many enzymes. In most cases, riboflavin (vitamin B(2)) as a coenzyme represents the catalytic part of the holoenzyme. Riboflavin is an amphiphatic molecule and allows a large variety of different interactions with the enzyme itself and also with the substrate.
Matthias, Mack, Simon, Grill
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Riboflavin in Milk

Nature, 1956
SUCH studies as have been made on the riboflavin in milk point to the existence of species differences in respect of the forms in which this vitamin occurs in milk. Thus Kon and Mawson1 reported that the concentration of riboflavin in human milk is very low, and found that the method of Emmerie2, in which riboflavin is extracted by methanol was ...
V V, MODI, E C, OWEN
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Biosynthesis of Riboflavin

EcoSal Plus, 2010
The biosynthesis of riboflavin requires 1 equivalent of GTP and 2 equivalents of ribulose phosphate. The first committed reactions of the convergent pathway are catalyzed by GTP hydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase.
Markus, Fischer, Adelbert, Bacher
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Biotechnology of riboflavin

Applied Microbiology and Biotechnology, 2016
Riboflavin (vitamin B2) production has shifted from chemical synthesis to exclusive biotechnological synthesis in less than 15 years. The underlying extraordinary achievement in metabolic engineering and bioprocess engineering is reviewed in this article with regard to the two most important industrial producers Bacillus subtilis and Ashbya gossypii ...
Susanne Katharina, Schwechheimer   +4 more
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The chemiluminescence of riboflavin

Archives of Biochemistry and Biophysics, 1953
Abstract 1. 1. It has been found that the oxidation of riboflavin with peroxide produces light of approximately the same color as the fluorescence of riboflavin. 2. 2. Data concerning the temperature dependence of the reaction have been presented. 3. 3. Optimal luminescence without added metallic activators occurs around pH 7–8. 4. 4.
B L, STREHLER, C S, SHOUP
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Photochemistry of riboflavin

Experientia, 1962
Le spectre d'absorption, les caracteristiques luminescentes et photochimiques de la riboflavine sont presentes. L'interpretation des donnees experimentales d'autres auteurs sur la decomposition photochimique de l'eau sensibilisee par la riboflavine est critiquee.
G, OSTER, J S, BELLIN, B, HOLMSTROM
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Biosynthesis of riboflavin

2001
The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate. The imidazole ring of GTP is hydrolytically opened, yielding a 4,5-diaminopyrimidine that is converted to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction, and dephosphorylation ...
A, Bacher   +7 more
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RIBOFLAVIN IN PSORIASIS

Archives of Dermatology, 1956
It is with apprehension that one reports any new form of treatment for psoriasis. However, the results with a new form of riboflavin have been so encouraging in a limited number of cases that this preliminary report is issued. Relatively recent discoveries on the mode of action of riboflavin have suggested its use in some of the scaly skin diseases of
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