Premature farrowing and stillbirths in two organic sow farms due to riboflavin deficiency [PDF]
Porcine Health Management, 2023 Background Riboflavin deficiency can lead to premature farrowing, stillborn piglets, weak-born piglets and neonatal death. Riboflavin (vitamin B2) is considered essential for reproductive function. The longer the period on riboflavin-deficient diets, the
Camilla Torreggiani +7 more
doaj +5 more sources
Effects of riboflavin deficiency and high dietary fat on hepatic lipid accumulation: a synergetic action in the development of non-alcoholic fatty liver disease [PDF]
Nutrition & MetabolismBackground Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Riboflavin, one of water soluble vitamins, plays a role in lipid metabolism and antioxidant function.
Yanxian Wang +6 more
doaj +3 more sources
Riboflavin Deficiency-Implications for General Human Health and Inborn Errors of Metabolism. [PDF]
Int J Mol Sci, 2020 As an essential vitamin, the role of riboflavin in human diet and health is increasingly being highlighted. Insufficient dietary intake of riboflavin is often reported in nutritional surveys and population studies, even in non-developing countries with ...
Mosegaard S +5 more
europepmc +4 more sources
Altered cytoskeletal arrangement in induced pluripotent stem cells and motor neurons from patients with riboflavin transporter deficiency [PDF]
Disease Models & Mechanisms, 2021 The cytoskeletal network plays a crucial role in the differentiation, morphogenesis, function and homeostasis of the nervous tissue, so that alterations in any of its components may lead to neurodegenerative diseases.
Alessia Niceforo +8 more
doaj +3 more sources
Riboflavin transporter deficiency [PDF]
Definitions, 2020 Riboflavin transporter deficiency (RTD), comprising RTD2 and RTD3 (caused by biallelic pathogenic variants in SLC52A2 and SLC52A3, respectively) is a rare neurologic condition characterized by progressive peripheral and cranial neuronopathy that causes ...
INSERM
semanticscholar +3 more sources
Developmental riboflavin deficiency results in structural and functional changes in the neural retina and RPE [PDF]
Redox BiologyThe retina, a metabolically active tissue, relies on adequate flavin levels for optimal function. Our previous research demonstrated that ablation of RTBDN, a retina-specific riboflavin binding protein, plays a pivotal role in maintaining flavin levels ...
Xue Zhao +3 more
doaj +3 more sources
New Insights into the Neurodegeneration Mechanisms Underlying Riboflavin Transporter Deficiency (RTD): Involvement of Energy Dysmetabolism and Cytoskeletal Derangement [PDF]
Biomedicines, 2022 Riboflavin transporter deficiency (RTD) is a rare genetic disorder characterized by motor, sensory and cranial neuropathy. This childhood-onset neurodegenerative disease is caused by biallelic pathogenic variants in either SLC52A2 or SLC52A3 genes ...
Fiorella Colasuonno +5 more
doaj +3 more sources
Riboflavin Deficiency in Rats Decreases de novo Formate Production but Does Not Affect Plasma Formate Concentration. [PDF]
J Nutr, 2017 MacMillan L +5 more
europepmc +4 more sources
Riboflavin deficiency leads to irreversible cellular changes in the RPE and disrupts retinal function through alterations in cellular metabolic homeostasis [PDF]
Redox Biology, 2022 Ariboflavinosis is a pathological condition occurring as a result of riboflavin deficiency. This condition is treatable if detected early enough, but it lacks timely diagnosis.
Tirthankar Sinha +7 more
doaj +2 more sources
Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice. [PDF]
Sci Rep, 2020 Riboflavin transporter 3 (RFVT3), encoded by the SLC52A3 gene, is important for riboflavin homeostasis in the small intestine, kidney, and placenta. Our previous study demonstrated that Slc52a3 knockout (Slc52a3−/−) mice exhibited neonatal lethality and ...
Jin C +11 more
europepmc +2 more sources