Results 31 to 40 of about 19,244 (296)

Mixed Effect Modeling and Variable Selection for Quantile Regression [PDF]

, 2021
It is known that the estimating equations for quantile regression (QR) can be solved using an EM algorithm in which the M-step is computed via weighted least squares, with weights computed at the E-step as the expectation of independent generalized inverse-Gaussian variables.
arxiv   +1 more source

Transcriptional profiling of liver in riboflavin-deficient chicken embryos explains impaired lipid utilization, energy depletion, massive hemorrhaging, and delayed feathering

BMC Genomics, 2018
Background A strain of Leghorn chickens (rd/rd), unable to produce a functional riboflavin-binding protein, lays riboflavin-deficient eggs, in which all embryos suddenly die at mid-incubation (days 13-15).
Larry A. Cogburn, Danielle N. Smarsh, Xiaofei Wang, Nares Trakooljul, Wilfrid Carré, Harold B. White   +5 more
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Riboflavin - properties, occurrence and its use in medicine

Pteridines, 2019
Riboflavin is built on an isoalloxazin ring, which contains three sixcarbon rings: benzoic, pyrazine and pyrimidine. Riboflavin is synthesized by some bacteria, but among humans and animals, the only source of flavin coenzymes (FAD, FMN) is exogenous ...
Szczuko Małgorzata, Ziętek Maciej, Kulpa Danuta, Seidler Teresa   +3 more
doaj   +1 more source

Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1)

Frontiers in Molecular Neuroscience, 2021
Riboflavin, also known as vitamin B2, isfound in foods and is used as a dietary supplement. Its deficiency (also called ariboflavinosis) results in some skin lesions and inflammations, such as stomatitis, cheilosis, oily scaly skin rashes, and itchy ...
Kihwan Lee, Young In Choi, Sang-Taek Im, Sung-Min Hwang, Han-Kyu Lee, Jay-Zoon Im, Yong Ho Kim, Sung Jun Jung, Chul-Kyu Park   +8 more
doaj   +1 more source

Non-invasive detection of nanoscale structural changes in cornea associated with cross-linking treatment [PDF]

, 2020
Corneal cross-linking (CXL) using UVA irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as keratoconus. To characterize the corneal structural changes, existing methods such as X-ray microscopy, transmission electron microscopy (TEM ...
arxiv   +1 more source

Theranostic‐guided corneal cross‐linking: Preclinical evidence on a new treatment paradigm for keratoconus

Journal of Biophotonics, Volume 15, Issue 12, December 2022., 2022
Theranostics is an emerging therapeutic paradigm of personalized and precision medicine that performs therapy guided by molecular diagnostic imaging. The technology was implemented in a UV‐A medical device and showed to efficiently drive the operator in performing personalized riboflavin/UV‐A corneal cross‐linking for treatment of corneal disorders ...
Giuseppe Lombardo, Giuseppe Massimo Bernava, Sebastiano Serrao, Marco Lombardo   +3 more
wiley   +1 more source

Suspected outbreak of riboflavin deficiency among populations reliant on food assistance: a case study of drought-stricken Karamoja, Uganda, 2009-2010. [PDF]

PLoS ONE, 2013
BACKGROUND: In 2009, a humanitarian response was launched to address a food security and livelihoods crisis in Karamoja, Uganda. During a polio immunization campaign in mid-August 2009, health workers in Nakapiripit District reported a concern about an ...
Erin K Nichols, Leisel E Talley, Nelly Birungi, Amanda McClelland, Elizabeth Madraa, Agnes B Chandia, Jacqueline Nivet, Rafael Flores-Ayala, Mary K Serdula   +8 more
doaj   +1 more source

Altered cytoskeletal arrangement in induced pluripotent stem cells and motor neurons from patients with riboflavin transporter deficiency

Disease Models & Mechanisms, 2021
The cytoskeletal network plays a crucial role in the differentiation, morphogenesis, function and homeostasis of the nervous tissue, so that alterations in any of its components may lead to neurodegenerative diseases.
Alessia Niceforo, Chiara Marioli, Fiorella Colasuonno, Stefania Petrini, Keith Massey, Marco Tartaglia, Enrico Bertini, Sandra Moreno, Claudia Compagnucci   +8 more
doaj   +1 more source

Quality marker prediction in Trillium tschonoskii based on UHPLC–MS chemical characterisation and network pharmacology

Phytochemical Analysis, Volume 34, Issue 1, Page 76-91, January 2023., 2023
Abstract Introduction As a folk herbal medicine, Trillium tschonoskii has been used for thousands of years. However, due to the complexity of the chemical constituents of this herb, few investigations have acquired a comprehensive understanding of its quality markers.
Zhixin Wang, Rao Fu, Na Zhu, Junqi Wang, Xiaorui Zhang, Xiulan Huang, Zhiyong Li   +6 more
wiley   +1 more source