Results 111 to 120 of about 156,401 (384)

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

A possible mechanism for cold denaturation of proteins at high pressure [PDF]

, 2003
We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the pressure where
A. Hansen, A. Trovato, B. L. Chen, B. L. Chen, B. Lee, C -J. Tsai, C. N. Pace, C. Vanderzande, D. Chandler, E. Paci, F. H. Stillinger, G. Caldarelli, G. Hummer, G. P. Privalov, G. Panick, G. W. Robinson, H. Ludwing, H. S. Chan, H. S. Frank, J. Jonas, J. Zhang, J. Zipp, K. A. Dill, K. A. Dill, K. A. Dill, K. A. Dill, K. A. T. Silverstein, K. C. Cho, K. F. Lau, L. R. Pratt, L. Smeller, M. W. Mahoney, N. Muller, O. Collet, P. Bruscolini, P. L. Privalov, P. L. Privalov, P. R. ten Wolde, P. R. ten Wolde,, R. A. Pierotti, S. A. Hawley, S. A. Hawley, S. Chan, S. J. Gill, S. Kunugi, S. Shimizu, S. Shimizu, V. A. Payne, V. F. Petrenko, W. Kauzmann, Y. Nozaki   +50 more
core   +3 more sources

Ribonucleases as antiviral agents [PDF]

Molecular Biology, 2014
Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review discusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and ...
Ilinskaya O., Mahmud R.
openaire   +5 more sources

Positive Darwinian selection after gene duplication in primate ribonuclease genes.

Proceedings of the National Academy of Sciences of the United States of America, 1998
Evolutionary mechanisms of origins of new gene function have been a subject of long-standing debate. Here we report a convincing case in which positive Darwinian selection operated at the molecular level during the evolution of novel function by gene ...
Jianzhi Zhang, H. Rosenberg, M. Nei
semanticscholar   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Development of a new class of chemical and biological ultrasensors: Ribonuclease contamination and control [PDF]

In order to define ribonuclease contamination, an assay for ribonuclease having picogram level sensitivity was established. In this assay, polycytidylic acid is digested by ribonuclease leading to smaller fragments of poly C that remain soluble after ...

core   +1 more source

Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA

Nature, 2010
Ribonuclease (RNase) P is the universal ribozyme responsible for 5′-end tRNA processing. We report the crystal structure of the Thermotoga maritima RNase P holoenzyme in complex with tRNAPhe. The 154 kDa complex consists of a large catalytic RNA (P RNA),
N. J. Reiter, Amy K. Osterman, A. Torres-Larios, K. Swinger, T. Pan, A. Mondragón   +5 more
semanticscholar   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Azotobacter vinelandii RNA polymerase. II - Effect of ribonuclease on polymerase activity [PDF]

Ribonuclease effect on polymerase activity during ribonucleic acid synthesis ...
Krakow, J. S.
core   +1 more source

Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences. [PDF]

, 2017
External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA.
Li, Wei, LIU, Fenyong, Liu, Yujun, Lu, Sangwei, Sheng, Jingxue, Sun, Xu, Trang, Phong, Vu, Gia-Phong, Xu, Mengqiong, Yang, Zhu   +9 more
core   +2 more sources