Results 201 to 210 of about 132,332 (305)

A pathogenesis related protein, TCPR10 from Theobrama cacao with antifungal activity against Moniliophthora perniciosa [PDF]

, 2007
Alves Melo, Sarah, Cascardo, Julio Cezar M., Da Silva, Aline Clara, Gesteira, Abelmon, Micheli, Fabienne, Pungartnik, Cristina   +5 more
core  

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Ribonuclease RNase Z is an evolutionarily conserved deAMPylase. [PDF]

Proc Natl Acad Sci U S A
Mukherjee M, Pon A, Goldberg T, Pawłowski K, Sreelatha A.   +4 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

BR-bodies facilitate adaptive responses and survival during copper stress in Caulobacter crescentus. [PDF]

J Biol Chem
Passos C, Tomares DT, Yassine H, Schnorr WE, Hunter H, Wolfe-Feichter HK, Velier J, Dzurik KG, Grillo J, Gega A, Saxena S, Schrader JM, Childers WS.   +12 more
europepmc   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Saprotrophic Arachnopeziza Species as New Resources to Study the Obligate Biotrophic Lifestyle of Powdery Mildew Fungi. [PDF]

Mol Ecol Resour
Loos A, Doykova E, Qian J, Kümmel F, Ibrahim H, Kiss L, Panstruga R, Kusch S.   +7 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria. [PDF]

Proc Natl Acad Sci U S A
Colautti J, Garrett SR, Whitney JC.
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source