Results 211 to 220 of about 145,501 (289)

CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage. [PDF]

open access: yesNat Commun
Van Riper J   +5 more
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

open access: yesAdvanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang   +17 more
wiley   +1 more source

Transcriptome-based meta-analysis of drought stress regulatory genes in tomato. [PDF]

open access: yesBMC Plant Biol
Murtaza M   +12 more
europepmc   +1 more source

The study on the burst phase of ribonuclease A folding using a rapid mixing device

open access: diamond, 2000
Tetsunari Kimura   +5 more
openalex   +2 more sources

Structural properties of trimers and tetramers of ribonuclease A [PDF]

open access: bronze, 2001
Arianna Nenci   +3 more
openalex   +1 more source

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

open access: yesAdvanced Science, EarlyView.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo   +14 more
wiley   +1 more source

Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans. [PDF]

open access: yesNat Commun
Kyriakakis E   +5 more
europepmc   +1 more source

Action of dimeric ribonucleases on double‐stranded RNA [PDF]

open access: bronze, 1972
Giuseppe D’Alessio   +2 more
openalex   +1 more source

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