Results 241 to 250 of about 132,332 (305)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Altered tear fluid protein expression in persons with mild cognitive impairment. [PDF]

J Alzheimers Dis
Kärkkäinen V, Saari T, Rusanen M, Uusitalo H, Leinonen V, Thiede B, Koivisto AM, Kaarniranta K, Utheim TP.   +8 more
europepmc   +1 more source

Transcriptome-based meta-analysis of drought stress regulatory genes in tomato. [PDF]

BMC Plant Biol
Murtaza M, Aqeel M, Waheeb SA, Rehman N, Irum S, Almahasheer H, Zahed R, Hassan RN, Fiaz S, Uzair M, Khan MR, Ali GM, Jaremko M.   +12 more
europepmc   +1 more source

Dicer Neosynthesis Regulates Platelet Reactivity: A Mechanism Altered in Type 2 Diabetes. [PDF]

Circ Res
Bury L, Piselli E, Manni G, Momi S, Ciarrocca Taranta G, Guglielmini G, Fanelli C, De Fano M, Rowley JW, Weyrich AS, Gresele P.   +10 more
europepmc   +1 more source

OsRNS4-mediated cross-kingdom RNA interference is inhibited by <i>Ustilaginoidea virens</i> effector SCRE2 to promote infection in rice. [PDF]

Sci Adv
Gao H, Fang A, Yang W, Qiu S, Zheng X, Wang S, Fan J, Guo H, Cui F, Lee YH, Wang J, Sun W.   +11 more
europepmc   +1 more source

The HigB-like SehA toxin promotes non-replicating Salmonella inside macrophages by inhibiting ribonuclease III-dependent rRNA maturation. [PDF]

Nucleic Acids Res
Choi S, Cho YJ, Baek S, Choi E, Kim YK, Choi TS, Lee EJ.   +6 more
europepmc   +1 more source

Identification of a Novel Intracellular Function of the Secreted Ribonuclease RNASE1 in Inhibiting Gene Expression. [PDF]

Mol Cell Biol
Singh R, Archibald A, Li XL, Kumar R, Das S, Pehrsson EC, Zhao PX, Wen X, Chari R, Grammatikakis I, Lal A.   +10 more
europepmc   +1 more source

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Ribonuclease A

Chemical Reviews, 1998
Ronald T Raines
exaly   +3 more sources