Results 121 to 130 of about 49,990 (134)
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Ribonuclease H activities associated with herpes simplex virus
Biochemical and Biophysical Research Communications, 1974Abstract Ribonuclease H activities were detected in purified particles of herpes simplex virus type 1 and 2. The RNase H specifically degrades the ribo moiety of the synthetic homopolymet [ 3 H]-poly rA·dT as well as the RNA part of the hybrid [ 3 H]-RNA·DNA duplex. Single-stranded polymers were not degraded under the conditions used.
Hans Fischer +2 more
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Biochemical and Biophysical Research Communications, 1978
Summary The specific activity of Mg 2+ -dependent ribonuclease H (RNase H) from rat liver nuclei increased three- to four-fold within 24 h of a single injection of thioacetamide, and decreased to normal values 48 h after administration. The response of RNase H activity to thioacetamide was very similar to that of RNA polymerase I after treatment. The
Fumiyasu Sato +3 more
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Summary The specific activity of Mg 2+ -dependent ribonuclease H (RNase H) from rat liver nuclei increased three- to four-fold within 24 h of a single injection of thioacetamide, and decreased to normal values 48 h after administration. The response of RNase H activity to thioacetamide was very similar to that of RNA polymerase I after treatment. The
Fumiyasu Sato +3 more
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Targeting the retroviral ribonuclease H by rational drug design
AIDS, 2012Ribonucleases H or RNases H are conserved and exist in almost every organism. They generate and remove RNA primers, which are required for DNA replication. RNases H hydrolyze RNA in RNA-DNA hybrids. RNases H and related enzymes contribute to reduction of gene expression in antisense and small-interfering RNA mechanisms for gene silencing.
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Development of a Nonradioactive Ribonuclease H Assay
Analytical Biochemistry, 1996Z. Hostomsky +3 more
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The metallobiochemistry of ribonuclease H.
Journal of Inorganic Biochemistry, 1991J.A. Cowan, Ruwen Jou
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1995
Abstract The ribonuclease H (RNase H) is an essential activity associated with HIV reverse transcriptase (RT). RNase H cleaves the RNA in hybrid RNA-DNA intermediates during minus-strand DNA synthesis initiated from the tRNALys, 3 primer.
Z Hostomska, Z Hostomsky
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Abstract The ribonuclease H (RNase H) is an essential activity associated with HIV reverse transcriptase (RT). RNase H cleaves the RNA in hybrid RNA-DNA intermediates during minus-strand DNA synthesis initiated from the tRNALys, 3 primer.
Z Hostomska, Z Hostomsky
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Ribonuclease H Inhibitors: Structural and Molecular Biology
2013PR, IN, and RT are the only enzymes encoded by the HIV genome, and all are targeted by antiviral therapeutic agents (De Clercq 2009). HIV PR cleaves viral polyprotein precursors to produce mature virus and is targeted by PR inhibitors saquinavir, ritonavir, and several others. IN is required for assimilation of viral DNA into the genome of the infected
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The Direction of Ribonucleases H by Antisense Oligodeoxynucleotides
2003R V Giles, D M Tidd
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Evaluation of Retroviral Ribonuclease H Activity
2003Jason W. Rausch +2 more
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