Results 111 to 120 of about 11,347,920 (284)

Evolution of ribonuclease H genes in prokaryotes to avoid inheritance of redundant genes-0

, 2011
Copyright information:Taken from "Evolution of ribonuclease H genes in prokaryotes to avoid inheritance of redundant genes"http://www.biomedcentral.com/1471-2148/7/128BMC Evolutionary Biology 2007;7():128-128.Published online 31 Jul 2007PMCID:PMC1950709 ...
Hiromi Kochiwa (78698), Akio Kanai (70451), Masaru Tomita (22488)   +2 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Cytotoxicity of Polyspermine-Ribonuclease A and Polyspermine-Dimeric Ribonuclease A

, 2007
Polyspermine-ribonuclease A (PS-RNase A) and polyspermine-dimeric ribonuclease A (PS-dimeric RNase A) were prepared by cross-linking ribonuclease A or its covalently linked dimer to polyspermine (PS) using dimethyl suberimidate.
M. MORBIO, D. V. LAURENTS, DONADELLI, Massimo, COSTANZO, Chiara, J. SOUCEK, LIBONATI, Massimo, VOTTARIELLO, FRANCESCA, J. MATOUSEK, P. POUCKOVA, GOTTE, Giovanni   +9 more
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori

iScience
Summary: Ribonucleases are involved in several biological processes, including the turnover of structural and messenger RNAs and the specific processing of the cellular transcriptome. Here, we characterized the RNase Y from Helicobacter pylori.
Federico D’Agostino, Eva Pinatel, Alexandra Meynhardt, Vincenzo Scarlato, Andrea Vannini, Davide Roncarati   +5 more
doaj   +1 more source

Molecular Diversities and Functions of Ribonucleases H

Seibutsu Butsuri, 2003
Ribonuclease H specifically cleaves the RNA strand of RNA/DNA hybrids. Based on the difference in the amino acid sequences, RNases H are classified into two major families, Type 1 and Type 2 RNases H. Type 1 and Type 2 RNases H share a common three-dimensional structure despite their poor amino acid sequence similarity.
openaire   +2 more sources

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

A mid-throughput HBV replication inhibition assay capable of detecting ribonuclease H inhibitors. [PDF]

J Virol Methods, 2021
Li Q, Edwards TC, Ponzar NL, Tavis JE.
europepmc   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Plasmid replication based on the T7 origin of replication requires a T7 RNAP variant and inactivation of ribonuclease H. [PDF]

Nucleic Acids Res, 2021
Becker K, Meyer A, Roberts TM, Panke S.
europepmc   +1 more source