Identification of novel components of Trypanosoma brucei editosomes [PDF]
, 2003 The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Carmean, Nicole +6 more
core +2 more sources
Stage-specific expressions of four different ribonuclease H genes in Leishmania [PDF]
, 2005 The human pathogen of the genus Leishmania cause worldwide morbidity and infection of visceral organs by some species may be lethal. Lack of rational chemotherapy against these pathogens dictates the study of differential biochemistry and molecular ...
Chaudhuri, Gautam +2 more
core
Ensemble Bayesian Analysis of Bistability in a Synthetic Transcriptional Switch [PDF]
, 2012 An overarching goal of synthetic and systems biology is to engineer and understand complex biochemical systems by rationally designing and analyzing their basic component interactions.
Kim, Jongmin +2 more
core +1 more source
On the Stabilizing Action of Protein Denaturants: Acetonitrile Effect on Stability of Lysozyme in Aqueous Solutions [PDF]
, 2000 Stability of hen lysozyme in the presence of acetonitrile (MeCN) at different pH values of the medium was studied by scanning microcalorimetry with a special emphasis on determination of reliable values of the denaturational heat capacity change.
Kovriguine, Evgueni, Potekhin, Sergey A.
core +2 more sources
ConSole: using modularity of contact maps to locate solenoid domains in protein structures. [PDF]
, 2014 BackgroundPeriodic proteins, characterized by the presence of multiple repeats of short motifs, form an interesting and seldom-studied group. Due to often extreme divergence in sequence, detection and analysis of such motifs is performed more reliably on
Godzik, Adam, Hrabe, Thomas
core +4 more sources
The hepatitis B virus ribonuclease H as a drug target [PDF]
Antiviral Research, 2015 Chronic hepatitis B virus (HBV) infection is a leading cause of hepatitis, liver failure, and hepatocellular carcinoma. An outstanding vaccine is available; however, the number of infections remains high. Current anti-HBV treatments with interferon α and nucleos(t)ide analogs clear the infection in only a small minority of patients, and either induce ...
Elena Lomonosova, John E. Tavis
openaire +3 more sources
Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway [PDF]
, 2014 In contrast to molecular chaperones that couple protein folding to ATP hydrolysis, protein disulfide-isomerase (PDI) catalyzes protein folding coupled to formation of disulfide bonds (oxidative folding).
A Jansens +54 more
core +3 more sources
Yeast ribonuclease H(70) cleaves RNA‐DNA junctions [PDF]
FEBS Letters, 1986 A specific substrate, M 13 DNA:RNA‐[32P]DNA, was synthesized to investigate the mode of cleavage of enzymes with RNase H activity. RNase H(70) from Saccharomyces cerevisiae hydrolyzes the phosphodiester bond at the RNA‐DNA junction of this substrate, thereby producing a 5'‐monophosphate‐terminated polydeoxyribonucleotide and 3'‐hydroxyl‐terminated ...
Ulrike Wintersberger, Robert Karwan
openaire +3 more sources
Bistability of an In Vitro Synthetic Autoregulatory Switch [PDF]
, 2011 The construction of synthetic biochemical circuits is an essential step for developing quantitative understanding of information processing in natural organisms.
Kim, Jongmin +2 more
core
HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors [PDF]
Viruses, 2010 Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse transcriptase (RT) of HIV has been a main target for antiviral drugs.
Matthias Götte, Greg L. Beilhartz
openaire +4 more sources