The World of Stable Ribonucleoproteins and Its Mapping With Grad-Seq and Related Approaches
Frontiers in Molecular Biosciences, 2021 Macromolecular complexes of proteins and RNAs are essential building blocks of cells. These stable supramolecular particles can be viewed as minimal biochemical units whose structural organization, i.e., the way the RNA and the protein interact with each
Milan Gerovac +4 more
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Application of CRISPR/Cas9 Tools for Genome Editing in the White-Rot Fungus Dichomitus squalens
Biomolecules, 2021 Dichomitus squalens is an emerging reference species that can be used to investigate white-rot fungal plant biomass degradation, as it has flexible physiology to utilize different types of biomass as sources of carbon and energy. Recent comparative (post-
Joanna E. Kowalczyk +2 more
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Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]
, 1994 To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV +4 more
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The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture
mBio, 2022 The Bunyavirales order is the largest group of negative-sense RNA viruses, containing many lethal human pathogens for which approved anti-infective measures are not available.
Francis R. Hopkins +7 more
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Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia [PDF]
, 2017 Telomeres are protective repeats of TTAGGG sequences located at the end of human chromosomes. They are essential to maintain chromosomal integrity and genome stability.
Bezares, Raimundo F. +6 more
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Diverse roles of heterogeneous nuclear ribonucleoproteins in viral life cycle
Frontiers in Virology, 2022 Understanding the host-virus interactions helps to decipher the viral replication strategies and pathogenesis. Viruses have limited genetic content and rely significantly on their host cell to establish a successful infection.
Krishna Bhattarai, Martin Holcik
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Immunoregulatory soluble CTLA-4 modifies effector T cell responses in systemic lupus erythematosus [PDF]
, 2016 Acknowledgments This work was supported by Arthritis Research UK (Grant no. 19282). We are grateful to Dr. Nick Fluck for his invaluable support in recruiting patients for the study, and Mrs.
Barker, Robert N. +6 more
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A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Nature Nanotechnology, 2019 Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing system often require viral vectors, which pose safety concerns for therapeutic genome editing1.
Guojun Chen +9 more
semanticscholar +1 more source
Genome Editing in Bacteria: CRISPR-Cas and Beyond
Microorganisms, 2021 Genome editing in bacteria encompasses a wide array of laborious and multi-step methods such as suicide plasmids. The discovery and applications of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas based technologies have ...
Ruben D. Arroyo-Olarte +2 more
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Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]
, 2013 Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
An, Wenfeng +5 more
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