Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia [PDF]
, 2017 Telomeres are protective repeats of TTAGGG sequences located at the end of human chromosomes. They are essential to maintain chromosomal integrity and genome stability.
Bezares, Raimundo F. +6 more
core +1 more source
Nature Biomedical Engineering, 2017 Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR associated protein 9 (Cas9)-based therapeutics, especially those that can correct gene mutations via homology-directed repair, have the potential to revolutionize the treatment of ...
Kunwoo Lee +21 more
semanticscholar +1 more source
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]
, 2012 Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas +47 more
core +4 more sources
Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes
Nature Communications, 2017 Substantial efforts are being made to optimize the CRISPR/Cas9 system for precision crop breeding. The avoidance of transgene integration and reduction of off-target mutations are the most important targets for optimization.
Zhen Liang +10 more
semanticscholar +1 more source
Frontiers in Plant Science, 2020 The genetic engineering method CRISPR has been touted as an efficient, inexpensive, easily used, and targeted genetic modification technology that is widely suggested as having the potential to solve many of the problems facing agriculture now and in the
Kali M. Brandt +3 more
doaj +1 more source
Synthetic gRNA/Cas9 Ribonucleoprotein Inhibits HIV Reactivation and Replication
Viruses, 2022 The current antiretroviral therapy (ART) for human immunodeficiency virus (HIV) can halt viral replication but cannot eradicate HIV infection because proviral DNA integrated into the host genome remains genetically silent in reservoir cells and is ...
Sushant Khanal +14 more
doaj +1 more source
Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]
, 2013 Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Bottcher, B. +4 more
core +1 more source
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Nature Nanotechnology, 2019 Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing system often require viral vectors, which pose safety concerns for therapeutic genome editing1.
Guojun Chen +9 more
semanticscholar +1 more source
Highly Efficient, Rapid and Co-CRISPR-Independent Genome Editing in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 We describe a rapid and highly efficient method to generate point mutations in Caenorhabditis elegans using direct injection of CRISPR-Cas9 ribonucleoproteins.
Harriet Prior +3 more
doaj +1 more source
Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]
, 2013 Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
An, Wenfeng +5 more
core +2 more sources