Results 201 to 210 of about 25,036 (270)

YRNAs: biosynthesis, structure, functions and involvment in cancer development. [PDF]

Discov Oncol
Campo A, Aliquò F, Velletri T, Campo S.
europepmc   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Staphylococcal nuclease and tudor domain-containing protein 1: An emerging therapeutic target in cancer (Review). [PDF]

Mol Clin Oncol
Rai SK, Khan MI, Kumar R, Patil RI, Dhawan S, Panwar A, Kumar A.   +6 more
europepmc   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

U11/U12 Small Nuclear Ribonucleoprotein TaU11/U12-35K Interacts with TaHis and Negatively Contributes to Fusarium Head Blight Resistance in Wheat. [PDF]

Int J Mol Sci
Song P, Li A, Deng J, Li D, Hu P, Guan Y, Zhang M, Liu Q, Hu H, Ru Z.   +9 more
europepmc   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

SNRPE is Associated with ERK/mTOR Signaling Activation and Reduced Autophagy to Promote Lung Adenocarcinoma Cell Proliferation. [PDF]

Onco Targets Ther
Yang J, Dai W, Ren B, Chen H, Dang X, Jiang L.   +5 more
europepmc   +1 more source

Protein tandem repeats that produce frameshifts can generate new structural states and functions

The FEBS Journal, Volume 293, Issue 3, Page 842-858, February 2026.
We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli, Gudrun Aldrian, Jeremy Leclercq, Theo Falgarone, Santiago M. Gómez Bergna, Denis N. Prada Gori, Andrew V. Oleinikov, Ilham Shahmuradov, Andrey V. Kajava   +8 more
wiley   +1 more source

SYNCAS‐mediated CRISPR‐Cas9 genome editing in the Jewel wasp, Nasonia vitripennis

Insect Molecular Biology, Volume 35, Issue 1, Page 48-55, February 2026.
Maternal injection of Cas9 RNP together with BAPC and saponins (SYNCAS) results in efficient gene editing of Nasonia vitripennis offspring. The timing of injection and egg collection is important for maximising efficiency and reducing screening effort.
Filippo Guerra, Sander De Rouck, Eveline C. Verhulst   +2 more
wiley   +1 more source

Alternative Splicing Dysregulation in Retinitis Pigmentosa: Pathogenic Mechanisms and Therapeutic Opportunities. [PDF]

Biomolecules
Jiang Y, Liu X, Fu J, Wu Y, Yu S, Yao K.
europepmc   +1 more source