Results 181 to 190 of about 38,830 (350)

Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease

open access: yesBrain Pathology, EarlyView.
Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez   +8 more
wiley   +1 more source

Immunosuppressive Effects of Multiple Myeloma‐Derived Extracellular Vesicles Through T Cell Exhaustion

open access: yesCancer Science, EarlyView.
Extracellular vesicles (EVs) derived from myeloma cells could potentially induce T cell exhaustion via the increase of the frequency of immune checkpoint marker‐positive CD8+ T cells and might thereby suppress T cell function. In addition, this immune escape mechanism from cytotoxic T cells is supported by the findings on SPHK1/S1P signaling from SPHK1‐
Shinya Hagiwara   +13 more
wiley   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

open access: yesCell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin   +4 more
wiley   +1 more source

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease

open access: yesCell Proliferation, EarlyView.
We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single‐cell RNA sequencing (scRNA‐seq), revealing club cell heterogeneity and cellular senescence in COPD.
Min Li   +5 more
wiley   +1 more source

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

open access: yesCell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu   +7 more
wiley   +1 more source

Some Physicochemical Properties of Ribonucleoprotein from Rat Liver Microsomes

open access: hybrid, 1962
Mary G. Hamilton   +2 more
openalex   +1 more source

Home - About - Disclaimer - Privacy