Results 211 to 220 of about 24,238 (294)

Impact of 14 days of head‐down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults

Experimental Physiology, EarlyView.
Abstract Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals show that exercise can mitigate these effects, but evidence remains scarce and inconclusive in older adults.
Jean‐Christophe Lagacé, Philippe St‐Martin, Mariano Avino, Ahmed Ghachem, Guy Hajj‐Boutros, Jose A. Morais, Jamie S. McPhee, Karen Lambert, Eléonor Riesco, Isabelle J. Dionne   +9 more
wiley   +1 more source

Neurod2 knockdown in <i>Xenopus laevis</i> tadpole brain retains cells in a proliferating, progenitor-like state. [PDF]

MicroPubl Biol
Beck CW, Banerjee S, Day RC.
europepmc   +1 more source

Circular RNAs: Unlocking new avenues in cardiometabolic disease management

The Journal of Physiology, EarlyView.
Abstract figure legend In the heart circular RNAs (circRNAs) function as microRNA sponges, interact with proteins and can even undergo translation. Advances in bioinformatics now enable their identification through high‐throughput RNA sequencing, whereas computational analyses reveal differential expression in cardiac disease settings.
Kimberley M. Mellor, Thomas D. Donelly, Gerald L.M. Naepi, Glenn D. Wadley, Bianca C. Bernardo   +4 more
wiley   +1 more source

csRNA and heparan sulfate : cell surface ribonucleoproteins regulate HS-mediated signaling

Signal Transduction and Targeted Therapy
Jinlin Li, Jiaxin Ling
doaj   +1 more source

Exosome-like nanovesicles from acerola for CRISPR-Cas9 ribonucleoprotein delivery to the central nervous system. [PDF]

Mol Ther Nucleic Acids
Nagamatsu Y, Umezu T, Hong T, Niijima T, Ohno SI, Harada Y, Kanekura K, Ochiya T, Kuroda M.   +8 more
europepmc   +1 more source

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia

The Journal of Physiology, EarlyView.
Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +13 more
wiley   +1 more source

Multidimensional regulatory roles and therapeutic applications of SRSF7 in cancer. [PDF]

Cell Death Discov
Li Y, Gao H, Zhang X, Sun F, Guo Y, Qiao X.   +5 more
europepmc   +1 more source

DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia

MedComm, Volume 7, Issue 7, July 2026.
DDX21 triggers CDK9 release from the 7SK RNP complex. DDX21‐CDK9 binding to HIFs drives transcriptional reprogramming during hypoxia. DDX21 enhances breast cancer progression and metastasis. Elevated DDX21 expression correlates with poor prognosis in breast cancer patients.
Guangqiang Li, Mingxia Deng, Leqing Zhu, Zhiwei Lei, Rong Guo, Xiong Liu, Renwang Chen, Xichun Xia, Qiong Wen, Yuanyuan Duan, Yan Chen, Zhinan Yin   +11 more
wiley   +1 more source

Resolving Sub-Nuclear Architecture from Compartments to Functional Domains. [PDF]

Int J Mol Sci
Cavallo M, Diaf A, Milanesi G, Biggiogera M, Casali C.   +4 more
europepmc   +1 more source

Co‐translational protein targeting to mitochondria in the context of co‐translational protein maturation

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondria import the majority of their proteins from the cytosol, creating a fundamental challenge: precursor proteins must be synthesized, maintained in an import‐competent state, and delivered to mitochondrial translocases without premature folding or aggregation. While mitochondrial protein import has been considered a post‐translational
Nikita A. Kvasov, Yury S. Bykov
wiley   +1 more source